ID Q17E72_AEDAE Unreviewed; 404 AA.
AC Q17E72;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN Name=5563704 {ECO:0000313|EnsemblMetazoa:AAEL003909-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL003909-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL003909-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL003909-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL003909-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL003909-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR RefSeq; XP_001647991.1; XM_001647941.1.
DR AlphaFoldDB; Q17E72; -.
DR STRING; 7159.Q17E72; -.
DR PaxDb; 7159-AAEL003909-PA; -.
DR EnsemblMetazoa; AAEL003909-RA; AAEL003909-PA; AAEL003909.
DR GeneID; 5563704; -.
DR KEGG; aag:5563704; -.
DR VEuPathDB; VectorBase:AAEL003909; -.
DR eggNOG; ENOG502QT7T; Eukaryota.
DR HOGENOM; CLU_042971_1_0_1; -.
DR InParanoid; Q17E72; -.
DR OMA; AAHSCQL; -.
DR OrthoDB; 5398335at2759; -.
DR Proteomes; UP000008820; Chromosome 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 106..309
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 404 AA; 45933 MW; 12B06256622B3FBF CRC64;
MEMKPISQKK RVSADLSALA ANGCDELGQN GHGGESETTP KETLKPGSKI RPVVTEEEVR
KLLERLYGII VLEMGEMDSY DDKNFLIQAD TLIKNPILKT YCPNGYVLKV ANTLDSEDEA
FFEGQTEIMH LLQAQHIICP VPVQNIFGKY QSLEKIGDGK HIVRLLEYVP GKVFHGVPHT
DRLFYEAGTF IAQIDSALKT IRHQGILKRQ SIWMLDNVPQ LKDFLYVIKD EHHKDIIEQV
LEAFEKRIVP NLAQFDKGVI YGDFNEHNII VSRKDEHAKE YEISGIIDFG DSCYSLYVFE
LAIAMAYMML ESNDLDTGGL VMAGYSMLRV IPQHEKDVLR VAIAARLCQS LVLGLYTSTV
DESNQYILST QARGWKILEA LWAEKDKDIL ERWEKVADEY LTRS
//
