ID Q17JF7_AEDAE Unreviewed; 1151 AA.
AC Q17JF7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=AAEL001986-PA {ECO:0000313|EMBL:EAT46884.1};
GN ORFNames=AAEL001986 {ECO:0000313|EMBL:EAT46884.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT46884.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT46884.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT46884.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT46884.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT46884.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT46884.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT46884.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477232; EAT46884.1; -; Genomic_DNA.
DR RefSeq; XP_001660806.1; XM_001660756.1.
DR AlphaFoldDB; Q17JF7; -.
DR STRING; 7159.Q17JF7; -.
DR PaxDb; 7159-AAEL001986-PA; -.
DR GeneID; 5573188; -.
DR KEGG; aag:5573188; -.
DR VEuPathDB; VectorBase:AAEL001986; -.
DR eggNOG; KOG0245; Eukaryota.
DR HOGENOM; CLU_001485_2_3_1; -.
DR OMA; EKDKQPC; -.
DR OrthoDB; 126886at2759; -.
DR PhylomeDB; Q17JF7; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}.
FT DOMAIN 170..536
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 675..728
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..616
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 264..271
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1151 AA; 129346 MW; BBF3E008B3437633 CRC64;
MNSNFTTPKS GGSRFGSKPL TPGRSNLVRP TVSASLVGAL KYTTTSSSSN ESLYQTPSSS
AMKKSKNPSA LFSNTKSKSS LALTPVSQFR PRSDSITSFK SCGGSTYGTP VDRLKKTRSA
LEGLAVGTPE CFSKVSLDSP AVLGGRPSGK LDESVKSVKE KDVLTAEISN LKVAVRVRPL
SAKECIDSVA NIVRVRENEV VVNAGNTADN SAGVEHCFQY DHAFWSCNAE DRSYVDQTGV
YNRLMKPLID KAFEGYNACL FAYGQTGSGK SYSMMGIDSD DMEISSEAGI IPRFCQELFC
RIEALKGKMQ AEVEVSYFEI YNEKIHDLLA VSPTEGVFSV TTSNVKKPPL KVREHPFWGP
YVVDLSTHPV DSHSALRNWL AVGNSQRATA ATGMNDKSSR SHSIFSVVLN LSEVISSEQR
NLNAVHQTKR SKISLVDLAG SERVSQTCGA SSERLKEGIS INKSLLTLGK VISALAETKR
SASTYIPYRD SVLTWLLREN LGGNSRTAML ATISPAVTHI DETLATLRYA CQARTIVNRV
KVNEDPHDRI IRELRAEVER LQVLRQDYER QKRLSANQQQ QPRKIIIETS VDDSEVEALR
LQLAETEQEL VKAQKSWRER LMEAEDVRRT EMKLLKRKGL ALELSAEQKE PCLVNLAADP
MLSGTLLYII PSGIVKVGRP SSFATPDIVL EGPLVSHHHC SIENRNGKLF LSPEDADQYE
TFVNGELVRE RRQLLHNDRV VIGGSHYFRV SNPLCPNRSK QIIVDFQSAH QEILREQEKR
LRRELDAEKQ AAISRIEAER IDHERQYEER LASLELEKFK YKCRQELLET EKEAMLKHST
DEEGDSTLVF TPFQSNLADE IRKIMERPSE ESLHQIQLMV KEATQRCKDL GLEFEFQQSQ
VLDEQGIFRA VVNIYDKSTG MVAEWLPARL EYWLSVVRDR EDLNEDNVFE NFDLEWKANV
EELSQPLNDS RSSRRISLNL TSVKDVILKR NSPAKKSPSH SARKSEGLLK SMFKFGASNP
GSVRKELFAE DGRNDENMPI NQQSPSPTKP HRFGVKANRQ LREIQVATAK LKKLCEKYQR
HNPADDSICT VLDLNSSTRS MEYVTRDFMQ SIAEIENAVQ DMRFVLTEQN VKHADDDDQE
RPGKSVRFLI D
//
