ID Q17L72_AEDAE Unreviewed; 1938 AA.
AC Q17L72;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN ORFNames=AAEL001442 {ECO:0000313|EMBL:EAT47423.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT47423.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT47423.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT47423.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT47423.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT47423.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT47423.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT47423.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR EMBL; CH477218; EAT47423.1; -; Genomic_DNA.
DR RefSeq; XP_001659298.1; XM_001659248.1.
DR STRING; 7159.Q17L72; -.
DR PaxDb; 7159-AAEL001442-PA; -.
DR VEuPathDB; VectorBase:AAEL001442; -.
DR eggNOG; KOG3570; Eukaryota.
DR HOGENOM; CLU_001270_0_0_1; -.
DR OMA; KILCLWR; -.
DR PhylomeDB; Q17L72; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475}.
FT DOMAIN 44..564
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 31..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1799
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1872..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1938 AA; 211474 MW; A54803A284BE7246 CRC64;
MAEQQQRDSL CPRLIDYLAI VGARSAVVTR PSAGNAPAGG TGSAQGGMHG AGPNTAPPVQ
IPELLRRYPP TDHADFPLPL DMVYFCQPEG CVSVGPRRTG SAVRDATSFV FTLTDKDSSK
TRYGICVNFY RPVEKYVAGV GGTGNLSGSR KGRNSTFRRE SWRKSMEKSS DSAFSRSSNI
APSDSSDRDC PSRRDSDPPN SIYHGSQQQT RLGVTGPSAD SESGGSHSPS PRASRKRSKI
RSHSLTSLCI LSHHPFLSTF RECLFILKKL IDACNDASSP KRVGASRQSG KDSVWNVLTS
QATESTPSVV LHDVKEIETW ILRLLSAPVP VPGSTRVEVE ILSPVIHQPL AFALPDHTRF
TLVDFPLHLP LELLGVDTCL KVLTLILLEH KIIIQSRDYN ALSMSVMALV HLIYPLEYMF
PVIPLLPTCM GSAEHFPQPL QVPGSASNSQ RSSFSGAAGT PRQPSPVGPP QPNPFLYGTD
VDSVDVATRV AMVRFFNSQN TLANFTEHTR TLRLYPRPVV AFQINSFLRS RPRASAFLNR
FARTQAVEWL AEWSLTPNNV AFLRVQTGVL DPAQVGDKPK WYAHTLTPIK FPVWDNTGSL
NGALKGMQQL ESQPTDESGS DSENAESTSS SYSSLSDFVS EIASSDLSPS LHDVYGNQHH
VHVAPKTLSS NLDPKLVYRP PSSLRYPEGM KPPQPEADDA DRPDSPTSTS SSRSDLSSPP
DSECEFNPKA RAEMQAAAKT AKEQQGSFEN ESDSNSTTTP KTIVSKESSG SLDAEGKRNR
LGKIPPPLSP NLGRQQSGSN ILARTSSSGS TGSSGHPPSL GSAGSQRQSS QGSLFEVLTS
QAKELVRETT RQSSQDGLLA HVDKLTLQAK KAAEEASKQA LEASKQAAGV SKNTLDDLTY
VGKSTFGDLT KTAKEAAAKK GLLHQGSQQS LQNQPTVSPS GSAVATTNQS LFSSITSDFN
GIAQSTSSMF SDLFGNKPSK QATQQQARTA AGNIQPNLNQ KQSKIKDKLS FDPFPGRKGL
VERTPLIKHS GPKQTQEEIQ RIQNAERSSS NSENQAFLKD LVNQVLAGEG VGWLKLNRLK
KLMEDESYRT LVLGKLNKTL ERKIGPDDHI DDVCITKPVY KGTLKCLLAT THGLENTVSN
FGLGGMASVF QMMEIAHTHY WSKDLSDNTT DLSASLLSSR SVSPMGSREN LRSPPSPSEP
GDWNSVVGSR KNSSVLNEPV ISRRPSENDN ENQSTTEMFK DMLTQKRNML LSKLTSFDSE
PGGGVHGSSG ALSVASDVLP QQQTGGPLIP SISCRSTVSD TEYEKHPKGS STLKDAKKMA
GGLFTGKSSL SAGFRYTGGS LIPTSNSPSP DAPRVYLFEG LLGKERSNVW DQMQFWEDAF
LDAVSQERDM IGMDQGPGEM MERYKSLSES ERKRLEHDED RLLSTMLYNL TAILVMLNCN
KLEIKRKIRR LLGKSHIGFI YAQEVNLLLD QINNLHGNDI DLKPLGSRLL HRQSFTVHQG
VDATGPLRFM EVRDDGLVLR SVNGTIVERW WFERLVNMTY SPKTRVLCLW RRNGGQTQLH
KYYTRKCKEL YVAIKEAMER GGCTGQGPEL GGEFPVQDLN SGEGGLMQIC LEGVGLLFAN
SKFFIRLEHI RKCFTQKGGV FILEEYNPKT RQLIQRKFMS NLADDICYSV LCVFSYVAAG
QEWQKKYPAI TLAGPAVHGT QQVVSLTTTT AQQQQLVTQQ APPATKLTTQ PVQPPTQSNQ
KIQQTHLPQQ TSPKLQTVIS KPIPQQQQIQ QQQQPTQRPQ PQQQPPPVSP VPQLKQPPSL
PARPSSSSSS SSSVTSSTTS ATSSEPPKMK APVLPSSAAP TGPTGRLPQQ SSLPNRGPPP
AIPPRIGLGQ RSGSVQIPSS SAGSAHQIRQ LKRQQSAASP PNQSSSPPHF PQQQQHHQQQ
FPQQRQNSRG SINSLRKN
//
