ID Q17ME6_AEDAE Unreviewed; 852 AA.
AC Q17ME6;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 106.
DE RecName: Full=Putative rRNA methyltransferase {ECO:0000256|HAMAP-Rule:MF_03163};
DE EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_03163};
DE AltName: Full=2'-O-ribose RNA methyltransferase SPB1 homolog {ECO:0000256|HAMAP-Rule:MF_03163};
GN Name=5579906 {ECO:0000313|EnsemblMetazoa:AAEL001037-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL001037-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL001037-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL001037-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL001037-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL001037-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: Probable methyltransferase involved in the maturation of rRNA
CC and in the biogenesis of ribosomal subunits. {ECO:0000256|HAMAP-
CC Rule:MF_03163}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-
CC methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_03163};
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03163}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03163}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_001657887.1; XM_001657837.1.
DR AlphaFoldDB; Q17ME6; -.
DR STRING; 7159.Q17ME6; -.
DR PaxDb; 7159-AAEL001037-PA; -.
DR EnsemblMetazoa; AAEL001037-RA; AAEL001037-PA; AAEL001037.
DR GeneID; 5579906; -.
DR KEGG; aag:5579906; -.
DR VEuPathDB; VectorBase:AAEL001037; -.
DR eggNOG; KOG1098; Eukaryota.
DR HOGENOM; CLU_009422_8_1_1; -.
DR InParanoid; Q17ME6; -.
DR OMA; DITTEDC; -.
DR OrthoDB; 119516at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0008649; F:rRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_01547; RNA_methyltr_E; 1.
DR HAMAP; MF_03163; RNA_methyltr_E_SPB1; 1.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR015507; rRNA-MeTfrase_E.
DR InterPro; IPR012920; rRNA_MeTfrase_SPB1-like_C.
DR InterPro; IPR024576; rRNA_MeTfrase_Spb1_DUF3381.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR028589; SPB1-like.
DR PANTHER; PTHR10920:SF13; PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3; 1.
DR PANTHER; PTHR10920; RIBOSOMAL RNA METHYLTRANSFERASE; 1.
DR Pfam; PF11861; DUF3381; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF07780; Spb1_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03163};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03163};
KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03163};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03163};
KW rRNA processing {ECO:0000256|HAMAP-Rule:MF_03163};
KW S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03163};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_03163}.
FT DOMAIN 24..199
FT /note="Ribosomal RNA methyltransferase FtsJ"
FT /evidence="ECO:0000259|Pfam:PF01728"
FT DOMAIN 236..396
FT /note="DUF3381"
FT /evidence="ECO:0000259|Pfam:PF11861"
FT DOMAIN 612..827
FT /note="Ribosomal RNA methyltransferase SPB1-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07780"
FT COILED 716..765
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT ACT_SITE 157
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT BINDING 56
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT BINDING 58
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT BINDING 76
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT BINDING 92
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
FT BINDING 117
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03163"
SQ SEQUENCE 852 AA; 97582 MW; 27EA94D25377D069 CRC64;
MGKKGKVGKD RKDKFYKLAK ETGYRSRAAF KLIQLNRRFG FLQQSQVCID LCAAPGGWMQ
VAKQNMPVSS VVIGIDLFPI KNVPGCISLV GDITSDKTKS DLAKELKTWK ADVVLNDGAP
NVGRNWLFDA YQQVCLTLSA VKLATQFLRP GGWFVTKVFR SKDYNALIWV LKQLFKKVHA
TKPSASRNES AEIFVVCQHY RAPDKIDPRF LDAKYVFEEL DVEPQVKVNL LKEVEKAKKP
KVEGYDGTDV RKIITVTEFL KEEKPLGLLG RVTEIRFDDK AISNHPRTTS EIKECCKDIK
VLGRKDLRDL LKWHKMMSSE LFPQEEKAEE ETKGKGKRVT KLNEQIEQEE AEGDDEETVE
LKSMEKEIAE LRKEEEQDAK RKRKKANKER AKLNEKLSLK MVIKGDEGPT EQADAMMFSL
NAVRSKKQMD DLLDADPDVL MEQDFHDDDD DGLPKKKQKF VKYDKETKGD LYEDEKVLAQ
KSDDEDSDAD LDREGLGLDD TEELQFENDD EAEEDVDSDN PDAQNPLITD LDYRDKEEKR
RQKAQLWFEK DTFKNVLAGE DQAVDYDLDR LTEMYRKSGA KIVGDDDKDR PLGKKARQRA
KHDVAKEDSS SDDSDSEAEV EDQSYEHKTV EKIGGKDGFE VVSTEKREKK VKLNEQELAL
GQLLVSGKKT KRDLIDAAWN RYMFNDSNLP EWFVKDEEKT MKKQAPVPHE VAETYKKNLE
EMNVRSIKKV MEAKARKKKH ATKRLEKIKK KAETIMENVD NTNQEKIRLL KKLYKKTDAK
KKDITYVVAK KSGTSGKKVR RPKGVEGRFK VVDPRMKKDR RAMDAKERRS AKKGGKKGGK
AKPGKGGKGK KK
//