ID Q17PY3_AEDAE Unreviewed; 2069 AA.
AC Q17PY3;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=AAEL000194 {ECO:0000313|EMBL:EAT48811.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT48811.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT48811.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48811.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT48811.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48811.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT48811.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48811.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; CH477188; EAT48811.1; -; Genomic_DNA.
DR RefSeq; XP_001658919.1; XM_001658869.1.
DR STRING; 7159.Q17PY3; -.
DR PaxDb; 7159-AAEL000194-PB; -.
DR GeneID; 5570029; -.
DR KEGG; aag:5570029; -.
DR VEuPathDB; VectorBase:AAEL000194; -.
DR eggNOG; KOG0902; Eukaryota.
DR OMA; TIEVWQS; -.
DR OrthoDB; 147843at2759; -.
DR PhylomeDB; Q17PY3; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1506..1681
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1788..2053
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2069 AA; 233979 MW; 1CA5F9A9737DA338 CRC64;
MLGNDRFSFQ KTVHCLARVL ARIKPTPWDK VQTLFRYCPQ ENAAGVFCLD SRAQDAVIAL
GLYFLESGYQ YEKEIIPYLL RLSKALPKAV WIDDVKLNKI DKIPIAEKFC FCLNSLLSDI
AVGCPESRDE IIVNQVEVLT VLTNMIKGSK ESSSLPPIIL CKATVPLLLG LGRSMGRYAT
ADPPLLCRLF PRDEIPSPKS QETPLVSLES KSNNTISQFR SIIPRSMSGS LTAELNEEKT
PKNNAKKLNS YYSVPYDPTT YFFSKYGSSF NQFPNMRFCD SPEKKNRLQF PINHLQAIFA
LAKKLLTKET LEHLDEQAGD IYSLHQIKPY GYKSVSETIN LVMVTLLREI LQNQTDLPTP
FTKDVQEFVK RLFLIGQTEL QNKQHDSTLD KVNDPSNIVV NKYKINVMAN AACVDLLVWA
IGDETEADKL CSRLYQKLNS VLGHKVVMDH MPLLMVCLEG LGKLAQKFPN IAGTSISYLR
DFLVDPSPIL TKLHAQSQAQ NKKDKENAPF RIVVQGSDFK AFDQQLNQRK GLTKSAHEAF
EALRDAAIEN LAIALKAAHA LDPYCVPALV ANVSNRLFTV EKQESESSLV SLNIIVMLGH
VAVALKDTPK TTNNILQFFI QRFCKVPSEQ NVLIVDQLGC MIISKCEAQV FEEIMKMFSR
VTVQAASLAY STNPEQRKSY HHVSDAVVNA LANIAANIQG ELEMLDLLGK LLELFVQIGL
EGERSYDSTS GAQKASSSAG NLGMLIPVIA VLVRRLPPIK NPKQRLHKLF KDFWLYCVVM
GFTNARLWPS DWYQGVQQIA AKSPLLISQI AHRSEMRELN YTSAIRSDSV SLNELRSQIL
VLLDHPPADI TQCINKLTFA QCTYLLSVYW LEILRVENAS EPSLEPILNY LCDNALLKDK
YGMWQCIRCI GDQVFEKFRS VLLAQDAVRE KVLESQAMLL LVYFNHIHKQ IQLVADQYLS
QLVDKFPHLL WNRKVLWCML DVLQLLAFSL TLDPNEETPT LRVASTPYTL QLMDSLPARE
SRVKDFADRC QGIVSEAMKW APKSTRSHLQ EYPNQVPTTT LSNHSGLALA VDSILHTWVT
NASIQSTSKR PHCVNSDTSK FVSVLCLRSK YAGEISGLLS VLEDEEKKGL ADRLVKDIWD
ACAEKSDAKQ RGALWRATAY LILCSSANRK LLHAISSSQV QLFTESAMET AVECWQWILT
ARQDLELCFI QEMVTAWQTT FDKRIGLFTE EVDITSPLAA YESCKLVPKP IVVAPHLIWL
QLLSEMVDTA KYCNRDKVEM FCMLLHRCLP FSRDFKMTRH ISTVGCRFKL LQCGLSLLQG
NTIPKSLARN ILRERIYANA LDYFCGPQLC PSQSREALLE DISILLKFWQ TMRSEKKHLV
ASEVSDYDLH PTSQNLSVNK SLDTVSLAGS EVARSTSSGN AGWYNTIPHS TSTLSKRSNR
IKRPPYQKDA YDKDYMKKRN LILELLAVEI EFMLIWANPL SSQELLIAGE EAVAEWRARP
VKLNVWRDYT RLAWSYNPAL AIFLPQRIRN AETIEDEVTR LVCSDPLAVI HIPEALKYLV
TTRTLLNEAP ELVYMLTWAR VNPIQALSYF SRQFPTHPLT AQYAVTTLNS YPAEAVLPYI
PQLVQALRHD TMGYVVEFIK HISKRSQIVA HQLIWNMQTN MYIDEEMHHK DPVLYDSLEA
LSQNIIASLS GPAKRFYERE FDFFGKITAV SGEIRSFPKG QARKKACLDA LSRIKVQAGC
YLPSNPEAMV LDIDYNSGTP MQSAAKAPYL ARFRVHRCGI NELESMAMEV SNNPNSQLDG
PKLSSMGPET WQAAIFKVGD DVRQDMLALQ VISIFKNIFQ QVGLELFLFP YRVVATAPGC
GVIECVPNAK SRDQLGRQTD SGLYEYFLHQ YGDETSKEFQ VARSNFVKSM AAYSVIGYLL
QIKDRHNGNI MIDKDGHIIH IDFGFMFESS PGGNIGFEPD LKLTDEMVMV MGGKMEAAPF
KWFCDLCVQS FLAIRPYQDA IVTLVSLMLD TGLPCFRGQT ITLLKQRFVP TKNNKEAAAH
MLGVIRNSYQ NFRTRTYDMI QYYQNQIPY
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