ID SPX3_BOVIN Reviewed; 495 AA.
AC Q17QZ3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE RecName: Full=Sugar phosphate exchanger 3;
DE AltName: Full=Solute carrier family 37 member 3;
GN Name=SLC37A3; Synonyms=SPX3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Unlike the other SLC37 members, lacks glucose-6-phosphate
CC antiporter activity. In osteoclasts, forms a transporter complex with
CC ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for
CC releasing N-BP molecules that have trafficked to lysosomes through
CC fluid-phase endocytosis into the cytosol.
CC {ECO:0000250|UniProtKB:Q8NCC5}.
CC -!- SUBUNIT: Interacts with ATRAID; the interaction is direct and both
CC proteins are mutually dependent for their stability.
CC {ECO:0000250|UniProtKB:Q8NCC5}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein
CC {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8NCC5}; Multi-
CC pass membrane protein {ECO:0000255}.
CC -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8NCC5}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC118104; AAI18105.1; -; mRNA.
DR RefSeq; NP_001068752.1; NM_001075284.1.
DR AlphaFoldDB; Q17QZ3; -.
DR SMR; Q17QZ3; -.
DR STRING; 9913.ENSBTAP00000033404; -.
DR GlyCosmos; Q17QZ3; 2 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000033404; -.
DR Ensembl; ENSBTAT00000033491.3; ENSBTAP00000033404.2; ENSBTAG00000012239.4.
DR Ensembl; ENSBTAT00000070087.1; ENSBTAP00000056723.1; ENSBTAG00000012239.4.
DR GeneID; 506910; -.
DR KEGG; bta:506910; -.
DR CTD; 84255; -.
DR VEuPathDB; HostDB:ENSBTAG00000012239; -.
DR VGNC; VGNC:34844; SLC37A3.
DR eggNOG; KOG2533; Eukaryota.
DR GeneTree; ENSGT00940000163296; -.
DR HOGENOM; CLU_001265_31_6_1; -.
DR InParanoid; Q17QZ3; -.
DR OMA; QPYELWN; -.
DR TreeFam; TF314991; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000012239; Expressed in saliva-secreting gland and 105 other cell types or tissues.
DR ExpressionAtlas; Q17QZ3; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006855; P:xenobiotic transmembrane transport; ISS:UniProtKB.
DR CDD; cd17342; MFS_SLC37A3; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000849; Sugar_P_transporter.
DR PANTHER; PTHR43184; MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B; 1.
DR PANTHER; PTHR43184:SF28; SUGAR PHOSPHATE EXCHANGER 3; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Lysosome; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..495
FT /note="Sugar phosphate exchanger 3"
FT /id="PRO_0000309277"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 495 AA; 54430 MW; 8CAB9BA81B161C5D CRC64;
MAWPRIFQRG ALLSRFSHHH MVVFLLTFFS YSLLHASRKT FSNVKVSISK QWTPSAFNKS
TELLPVEIWS SNHLFPSAEE ATLFLGMLDT IFLFSYAVGL FISGIVGDRL NLRWVLSFGM
CSSALVVFVF GTLTEWLHFY NKGLYCSLWI VNGLLQSTGW PCVVAVMGNW FGKAGRGVVF
GLWSACASVG NILGACLASS VLQYGYEYAF LVTAAVQFAG GIIIFFGLLV SPEEIGIPGI
ETEDNFEEDS HRPLINGAEN EDEAEPNYSI QEGNTVTQVK AISFYQACCL PGVIAYSLAY
ACLKLVNYSF FFWLPFYLSN NFGWKEAEAD QLSIWYDVGG IIGGTLQGFI SDMLQKRAPV
LALSLLLAIG SLVGYSRSPN DKSINALLMA VTGFFIGGPS NMISSAISAD LGRQELIQGS
SEALATVTGI VDGTGSIGAA VGQYLVSLIQ DNLGWMWVFY FFILMTSCTV LFISPLIVRE
TCSLMQRRQT RVLNE
//
