GenomeNet

Database: UniProt
Entry: Q17R09
LinkDB: Q17R09
Original site: Q17R09 
ID   PRP16_BOVIN             Reviewed;        1227 AA.
AC   Q17R09;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   16-OCT-2019, entry version 80.
DE   RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent RNA helicase DHX38;
DE   AltName: Full=DEAH box protein 38;
GN   Name=DHX38; Synonyms=PRP16;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable ATP-binding RNA helicase. Involved in pre-mRNA
CC       splicing as component of the spliceosome.
CC       {ECO:0000250|UniProtKB:Q92620}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000250|UniProtKB:Q92620}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92620}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. PRP16 sub-subfamily. {ECO:0000305}.
DR   EMBL; BC118085; AAI18086.1; -; mRNA.
DR   RefSeq; NP_001069266.1; NM_001075798.1.
DR   SMR; Q17R09; -.
DR   STRING; 9913.ENSBTAP00000042866; -.
DR   PaxDb; Q17R09; -.
DR   PRIDE; Q17R09; -.
DR   Ensembl; ENSBTAT00000045480; ENSBTAP00000042866; ENSBTAG00000013265.
DR   GeneID; 520046; -.
DR   KEGG; bta:520046; -.
DR   CTD; 9785; -.
DR   VGNC; VGNC:57044; DHX38.
DR   eggNOG; KOG0925; Eukaryota.
DR   eggNOG; COG1643; LUCA.
DR   GeneTree; ENSGT00940000156898; -.
DR   HOGENOM; HOG000175261; -.
DR   InParanoid; Q17R09; -.
DR   KO; K12815; -.
DR   OrthoDB; 354219at2759; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   ExpressionAtlas; Q17R09; baseline and differential.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; Isopeptide bond;
KW   mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Spliceosome; Ubl conjugation.
FT   CHAIN         1   1227       Pre-mRNA-splicing factor ATP-dependent
FT                                RNA helicase PRP16.
FT                                /FTId=PRO_0000282329.
FT   DOMAIN      542    705       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      727    902       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     555    562       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       652    655       DEAH box.
FT   MOD_RES      56     56       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   MOD_RES     117    117       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   MOD_RES     199    199       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   MOD_RES     224    224       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   MOD_RES    1194   1194       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   CROSSLNK    482    482       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   CROSSLNK    483    483       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   CROSSLNK    504    504       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q92620}.
FT   CROSSLNK   1166   1166       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q92620}.
SQ   SEQUENCE   1227 AA;  140405 MW;  4ACC6320AD6FE18C CRC64;
     MEDSGEDASL HRLEGTDVDS QVGGLIFKTK SAASEQHVFK APAPRPSLLG LDLLASLKRK
     EREEKDDGED KKKSRISSYK DWEESKDDQR DAEAEDSDQA GRSGRKDRHY RSARVETPSH
     PGGVSEEFWE RSRQRERERR EHGVYASSKD EKDRKKERSR DRDCDRKRDR DERDRSRHSG
     RSERDGGSDR SSRRNEPESP RHRPKDAATP SRSTWEEEDS GYGSSRRSQW ESPSPTPSYR
     DSERSHRPSS RDRDRSVRSR YSDDTPLPTP SYKYNEWADD RRHLGSTPRL SRGRGRREDG
     EEGISFDTEE ERQQWEDDQR QADRDWYMMD EGYDEFHNPL AYSSDDYVRR REQHLHKQKQ
     KRISAQRRQI NEDNERWETN RMLTSGVVHR LEVDEDFEED SAAKVHLMVH NLVPPFLDGR
     IVFTKQPEPV IPVKDATSDL AIIARKGSQT VRKHREQKER KKAQHKHWEL AGTKLGDIMG
     VKKEEEPDKS LTEDGKVDYR TEQKFADHMK KKSEASSEFA KKKSILEQRQ YLPIFAVQQE
     LLTIIRDNSI VIVVGETGSG KTTQLTQYLH EDGYTDYGMI GCTQPRRVAA MSVAKRVSEE
     MGGNLGEEVG YAIRFEDCTS ESTLIKYMTD GILLRESLRE ADLDHYSAII MDEAHERSLN
     TDVLFGLLRE VVARRSDLKL IVTSATMDAE KFASFFGNVP IFHIPGRTFP VDILFSKTPQ
     EDYVEAAVKQ SLQVHLSGAP GDILIFMPGQ EDIEVTSDQI VEHLEELENA PALAVLPIYS
     QLPSDLQAKI FQKAPDGVRK CIVATNIAET SLTVDGIMFV IDSGYCKLKV FNPRIGMDAL
     QIYPISQANA NQRSGRAGRT GPGQCFRLYT QSAYKNELLT TTVPEIQRTN LANVVLLLKS
     LGVQDLLQFH FMDPPPEDNM LNSMYQLWIL GALDNTGGLT STGRLMVEFP LDPALSKMLI
     VSCDMGCSSE ILLIVSMLSV PAIFYRPKGR EEESDQIREK FAVPESDHLS YLNVYLQWKN
     NNYSTIWCND HFIHAKAMRK VREVRAQLKD IMVQQRMSLA SCGTDWDIVR KCICAAYFHQ
     AAKLKGIGEY VNIRTGMPCH LHPTSSLFGM GYTPDYIVYH ELVMTTKEYM QCVTAVDGEW
     LAELGPMFYS VKQAGKSRQE NRRRAKEEAS AMEEEMALAE EQLRARRQEQ EKRSPLGSVR
     STKIYTPGRK EQGEPMTPRR TPARFGL
//
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