ID Q18156_CAEEL Unreviewed; 157 AA.
AC Q18156;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 2.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=TIL domain-containing protein {ECO:0000313|EMBL:CCD65652.2};
GN ORFNames=C25E10.7 {ECO:0000313|EMBL:CCD65652.2,
GN ECO:0000313|WormBase:C25E10.7}, CELE_C25E10.7
GN {ECO:0000313|EMBL:CCD65652.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65652.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD65652.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65652.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; BX284605; CCD65652.2; -; Genomic_DNA.
DR PIR; T15608; T15608.
DR RefSeq; NP_505344.2; NM_072943.2.
DR AlphaFoldDB; Q18156; -.
DR IntAct; Q18156; 1.
DR STRING; 6239.C25E10.7.1; -.
DR PaxDb; 6239-C25E10-7; -.
DR EnsemblMetazoa; C25E10.7.1; C25E10.7.1; WBGene00016096.
DR GeneID; 182891; -.
DR KEGG; cel:CELE_C25E10.7; -.
DR UCSC; C25E10.7; c. elegans.
DR AGR; WB:WBGene00016096; -.
DR WormBase; C25E10.7; CE50208; WBGene00016096; -.
DR eggNOG; ENOG502THSK; Eukaryota.
DR GeneTree; ENSGT00970000195908; -.
DR HOGENOM; CLU_092192_1_0_1; -.
DR InParanoid; Q18156; -.
DR OMA; CKPNACV; -.
DR OrthoDB; 2874608at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00016096; Expressed in larva and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR PANTHER; PTHR23259:SF59; PROTEIN CBG19171; 1.
DR PANTHER; PTHR23259; RIDDLE; 1.
DR Pfam; PF01826; TIL; 2.
DR SUPFAM; SSF57567; Serine protease inhibitors; 2.
PE 4: Predicted;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..157
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005693358"
FT DOMAIN 30..83
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
FT DOMAIN 90..144
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
SQ SEQUENCE 157 AA; 17454 MW; 69E7F4235C6A6666 CRC64;
MKTFLFLSFY LSMGSATQWI TPGAPFLPEC GKNQKRVACG YDCEPQCGFD PTVCSLECKP
NACVCKDGYV RNTKNDCVRR LECTAETSRC PEDEVFQTCG TLCQPTCDDP YPTSCEHDRC
IRNVCRCLPG LVRNSGTCTS LDECDNSPAR PLELFTL
//
