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Database: UniProt
Entry: Q18212
LinkDB: Q18212
Original site: Q18212 
ID   DX39B_CAEEL             Reviewed;         425 AA.
AC   Q18212; Q17323;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-OCT-2019, entry version 147.
DE   RecName: Full=Spliceosome RNA helicase DDX39B homolog;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein UAP56;
GN   Name=hel-1; ORFNames=C26D10.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 10-425.
RA   Melnick M.B., Lorenz L.J., Eberl D., Perrimon N.;
RL   Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=12810918; DOI=10.1261/rna.5480803;
RA   MacMorris M., Brocker C., Blumenthal T.;
RT   "UAP56 levels affect viability and mRNA export in Caenorhabditis
RT   elegans.";
RL   RNA 9:847-857(2003).
CC   -!- FUNCTION: Required for mRNA export out of the nucleus. May play a
CC       role in spliceosome assembly. {ECO:0000269|PubMed:12810918}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DECD
CC       subfamily. {ECO:0000305}.
DR   EMBL; Z54327; CAA91120.1; -; Genomic_DNA.
DR   EMBL; U08102; AAB65852.1; -; mRNA.
DR   PIR; T19484; T19484.
DR   RefSeq; NP_001021985.1; NM_001026814.3.
DR   SMR; Q18212; -.
DR   BioGrid; 39662; 19.
DR   IntAct; Q18212; 8.
DR   STRING; 6239.C26D10.2a; -.
DR   iPTMnet; Q18212; -.
DR   EPD; Q18212; -.
DR   PaxDb; Q18212; -.
DR   PeptideAtlas; Q18212; -.
DR   PRIDE; Q18212; -.
DR   EnsemblMetazoa; C26D10.2a.1; C26D10.2a.1; WBGene00001840.
DR   GeneID; 174333; -.
DR   KEGG; cel:CELE_C26D10.2; -.
DR   UCSC; C26D10.2a; c. elegans.
DR   CTD; 174333; -.
DR   WormBase; C26D10.2a; CE03025; WBGene00001840; hel-1.
DR   eggNOG; KOG0329; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   GeneTree; ENSGT00940000154912; -.
DR   InParanoid; Q18212; -.
DR   KO; K12812; -.
DR   OMA; CGYQKMT; -.
DR   OrthoDB; 779000at2759; -.
DR   PhylomeDB; Q18212; -.
DR   Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-CEL-72187; mRNA 3'-end processing.
DR   Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR   PRO; PR:Q18212; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001840; Expressed in 5 organ(s), highest expression level in multi-cellular organism.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000346; C:transcription export complex; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription factor complex; IPI:WormBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
DR   GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IGI:WormBase.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome;
KW   RNA-binding; Spliceosome.
FT   CHAIN         1    425       Spliceosome RNA helicase DDX39B homolog.
FT                                /FTId=PRO_0000055079.
FT   DOMAIN       72    245       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      257    418       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      85     92       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        41     69       Q motif.
FT   MOTIF       192    195       DECD box.
FT   CONFLICT    211    217       Missing (in Ref. 2; AAB65852).
FT                                {ECO:0000305}.
SQ   SEQUENCE   425 AA;  48493 MW;  7D6041E38AC3A44F CRC64;
     MEEEQLLDYE EEQEEIQDKQ PEVGGGDARK TKGTYASIHS SGFRDFLLKP EILRAIGDCG
     FEHPSEVQHE CIPQAILGMD VVCQAKSGMG KTAVFVITTL QQLEPVDGEV SVVCMCHTRE
     LAFQISKEYE RFSKYLPGVK VAVFFGGMAI KKDEERLAND CPHIVVGTPG RMLALARSGK
     LKLDKVKYFV LDECDKMIGD ADMRRDVQEI VKMTPQQKQV MMFSATLPKE LRTVCKRFMQ
     DPMEVYVDDE AKLTLHGLQQ HYVKLKEAEK NRRLLNLLDA LEFNQVVIFV KAVKRCEALH
     QLLTEQNFPS IAIHRQMAQE ERLSRYQAFK DFQKRILVAT DLFGRGMDIE RVNIVFNYDM
     PEDSDSYLHR VARAGRFGTK GLAITFVSDE NDAKTLNSVQ DRFDISITEL PEKIDVSTYI
     EGRTN
//
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