ID Q18394_CAEEL Unreviewed; 346 AA.
AC Q18394;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 174.
DE SubName: Full=Nuclear Hormone Receptor family {ECO:0000313|EMBL:CCD66532.1};
GN Name=nhr-140 {ECO:0000313|EMBL:CCD66532.1,
GN ECO:0000313|WormBase:C33G8.9};
GN ORFNames=C33G8.9 {ECO:0000313|WormBase:C33G8.9}, CELE_C33G8.9
GN {ECO:0000313|EMBL:CCD66532.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD66532.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD66532.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD66532.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; BX284605; CCD66532.1; -; Genomic_DNA.
DR PIR; T34130; T34130.
DR RefSeq; NP_504768.1; NM_072367.3.
DR AlphaFoldDB; Q18394; -.
DR SMR; Q18394; -.
DR PaxDb; 6239-C33G8-9; -.
DR EnsemblMetazoa; C33G8.9.1; C33G8.9.1; WBGene00016366.
DR GeneID; 3565647; -.
DR KEGG; cel:CELE_C33G8.9; -.
DR UCSC; C33G8.9; c. elegans.
DR AGR; WB:WBGene00016366; -.
DR WormBase; C33G8.9; CE06918; WBGene00016366; nhr-140.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00390000009496; -.
DR HOGENOM; CLU_007368_1_0_1; -.
DR InParanoid; Q18394; -.
DR OMA; QEEIVIC; -.
DR OrthoDB; 3020786at2759; -.
DR PhylomeDB; Q18394; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00016366; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR042936; Nhr-150.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46800:SF5; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR PANTHER; PTHR46800; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 1..72
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 93..345
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 346 AA; 40364 MW; 76CDAF6609E1207E CRC64;
MSCGVCGAKS SESHFGGLSC RACAAFFRRY VNSKKPQIEC TCSQKFDSSG PCRYCRMLKC
VEVGMAKCKV QATRQKNKEY VFLPCAITNI SLLSCNIIPR SCSKLTCTVK NWPDLDKKRR
DLYGGSMYNL NFTQFSNRVR QDTTIFWDLA ESIFSEIGLL NSDDKDALLC NFFPRWMLME
AAIEYCKNYE HHWKMIETDG LDNMLLVFYG SSMPKEKRLD DDKIIQIFRP YWTRFYIEIA
EPIHQEKCDK VEFMALFLLI LFDDAYLNIS EEAAKLCRNL QKVILRELKG YQMDNNCSEM
RFMDVISKLS LFERGEKRLQ EEIVICDVID ISLDEDFKTI MHIKKL
//
