ID Q18780_CAEEL Unreviewed; 1487 AA.
AC Q18780;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 3.
DT 24-JAN-2024, entry version 156.
DE SubName: Full=Lateral Signaling Target {ECO:0000313|EMBL:CCD64625.1};
GN Name=lst-6 {ECO:0000313|EMBL:CCD64625.1,
GN ECO:0000313|WormBase:C52E12.4};
GN ORFNames=C52E12.4 {ECO:0000313|WormBase:C52E12.4}, CELE_C52E12.4
GN {ECO:0000313|EMBL:CCD64625.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64625.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD64625.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64625.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; BX284602; CCD64625.1; -; Genomic_DNA.
DR PIR; T15824; T15824.
DR RefSeq; NP_495437.2; NM_063036.4.
DR AlphaFoldDB; Q18780; -.
DR SMR; Q18780; -.
DR STRING; 6239.C52E12.4.1; -.
DR EPD; Q18780; -.
DR PaxDb; 6239-C52E12-4; -.
DR PeptideAtlas; Q18780; -.
DR EnsemblMetazoa; C52E12.4.1; C52E12.4.1; WBGene00016889.
DR UCSC; C52E12.4; c. elegans.
DR AGR; WB:WBGene00016889; -.
DR WormBase; C52E12.4; CE31684; WBGene00016889; lst-6.
DR eggNOG; KOG1075; Eukaryota.
DR eggNOG; KOG2080; Eukaryota.
DR GeneTree; ENSGT00940000164647; -.
DR HOGENOM; CLU_004201_1_0_1; -.
DR InParanoid; Q18780; -.
DR OMA; KVTQEMY; -.
DR OrthoDB; 5398783at2759; -.
DR PhylomeDB; Q18780; -.
DR Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00016889; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17678; RUN2_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|EPD:Q18780,
KW ECO:0007829|PeptideAtlas:Q18780};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..621
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 801..1129
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1134..1239
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1332..1483
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 161..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1487 AA; 167451 MW; 39AF8EA241B561FE CRC64;
MSSNTTDIDV TLVDYFAVAG YDPDIGLVVD TKYDPGHTPC ESPGSSAPEF RPPLQRSFVA
KIINHFPQRR PGNPFSDDIL HLCMPRGLRF YTEKDVPKKL MIHTFANIKE DGSRINGTAL
TFYEEVKDLA ICDAMAQLQQ DHVREITARH NGIIEKQQRI HHPPGTVSGG THTLPRNRRD
RSKRISYYEG GGHNSLYMSR TICVLSRLPL VNSTRALLTA LHQIIASPSS PHLPLESYIY
WCLYEVPLPS PSMTLKIPLL GTTLVVQRPG PKELPFFDDS IGSIFDYLPV EKFIRLFSCF
LLEHQILLCS KDLSRLMTVC ESLLALSFPF RWQMTYAPVL PYSKLDFFEA PVPYVMGWYY
EDTVPEELFQ SNVCVVDLDT GRSELPEDVP VFPGARQLAT DIKNSLERLS DSDKMLTSTL
DRSEPEEVVV GGVKMRRKNK RPEDWAAKRM SRSFDLEDGS AMSEELSGMM RRPSRTGLQP
LPLENVLRNN STLARVAEIA RRAGVVVDVD NIKSEFADAQ NLDSPIARHY FVDAKVNNAI
RECVLNRFVE MFYSYEHFVI GGQGCDDRES YEANRESMAD FDKASFLSDQ PDSHLTFLAA
FLETQMFTSF IDSKILSQWE TPDEGVVLFD SRISAMRDLL GVSIVRTPTY EATPPFAATE
DLISKREETT DYVVPVPHTL AGAFPVRYEG AWPVHQLNTT LLDGANLISP APSPWRQRYP
RLRSQKDGSN GNSGQSVRPT SVYGGAGLMQ VESSKQIAQQ QYAFVQQLLK ETKAKTKRML
VDKMGKEAVQ LGHLDAGITG VEENTLVASF CDLLERIWAH GLKNKHGKSS LWNFVLQHQD
FEKPGLTTRA SSTSMLTPAI RGFRAPSLPP APQSTHNRRG GAPIDEVPAP IILSPQNNTD
MLTAISDIVD SFRGAQEEPW SKSLLRAATS IVEKYKNIEK DSNGNPLETN STLPSRYPIT
HPSIARARNQ SVEPFGLQIS GKSMKKSSSI GDFTNPAWGG SQTDVSNLGG YASVEGSPRK
MRSQSRTRSP DGARVVLSPL PTHVAYDLKN VLRMTEIKTD IGYARAFVRL ALERKLLHKH
LGALLSNSRV LRELYKPYAF VGSDEEKEQF LFHILSLNAA QFRCFTNTFT KTKMDYQVVI
VTGSGRGAIP AIWVTVEGSL CSTPPIMLKP NTPLFKFDHK NLGILSTLRI GHQQSEKPVQ
WFLEYVLVRN EITGQTYKFP CSKKFGEDRW FGNGEDITLE RMLVAEPFVE YDGNDNGIIE
QGEPFSPART RRMSSRSQTP QRERSPSNGR MAESSSRNRK TKVSEVEHLL GEAVNALVKY
FCSERKVKSE LAHLLCGQKG LVLAIEQAFQ LGRQESLLKY FRNTCPWDYI ERVCSWFFEL
CRKKEVDKLP KEQKTMIHHA LRLYRKIDAK TSLGKDGKFH VFVLLSIRDH ILPGLLPLMR
YSPVTADMYN EPSFLRTPAH MTYLAKLMYS LSEFNITIDP SLTYGIS
//
