ID Q18J41_HALWD Unreviewed; 160 AA.
AC Q18J41;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=folA2 {ECO:0000313|EMBL:CAJ51970.1};
GN OrderedLocusNames=HQ_1842A {ECO:0000313|EMBL:CAJ51970.1};
OS Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloquadratum.
OX NCBI_TaxID=362976 {ECO:0000313|EMBL:CAJ51970.1, ECO:0000313|Proteomes:UP000001975};
RN [1] {ECO:0000313|EMBL:CAJ51970.1, ECO:0000313|Proteomes:UP000001975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16790 / HBSQ001 {ECO:0000313|Proteomes:UP000001975};
RX PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA Bolhuis H.H., Palm P.P., Wende A.W., Falb M.M., Rampp M.M.,
RA Rodriguez-Valera F.F., Pfeiffer F.F., Oesterhelt D.D.;
RT "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT limits of water activity.";
RL BMC Genomics 7:169-169(2006).
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DR EMBL; AM180088; CAJ51970.1; -; Genomic_DNA.
DR RefSeq; WP_011571118.1; NC_008212.1.
DR AlphaFoldDB; Q18J41; -.
DR STRING; 362976.HQ_1842A; -.
DR GeneID; 4193990; -.
DR KEGG; hwa:HQ_1842A; -.
DR eggNOG; arCOG01490; Archaea.
DR HOGENOM; CLU_043966_5_2_2; -.
DR Proteomes; UP000001975; Chromosome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PIRSF; PIRSF000194; DHFR; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CAJ51970.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001975}.
FT DOMAIN 2..160
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 160 AA; 18284 MW; C28490A54C63A996 CRC64;
MEFTSVAALA DNYVIGRNGD LPWESLPADK QQYRERVSGF PVILGRRTYE SMRSDLPGRR
QIVLSQQKQG FHIETVTHAP DIDSAIEISK QTDTKTVYIL GGAAIYSLFQ SHIDRMVLTR
VPGIYQGDSY YPEWNDDVWT LISTEDYAGF TLEEWTRQSV
//
