ID OAR2_CAEEL Reviewed; 468 AA.
AC Q19084; Q3S1M1; Q7Z290;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 3.
DT 27-MAR-2024, entry version 147.
DE RecName: Full=Tyramine receptor tyra-2;
GN Name=tyra-2; ORFNames=F01E11.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15953361; DOI=10.1111/j.1471-4159.2005.03180.x;
RA Rex E., Hapiak V., Hobson R., Smith K., Xiao H., Komuniecki R.;
RT "TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in
RT the MC and NSM pharyngeal neurons.";
RL J. Neurochem. 94:181-191(2005).
CC -!- FUNCTION: G-protein coupled receptor for tyramine, a known
CC neurotransmitter and neuromodulator and direct precursor of octopamine.
CC Expression in amphidial sensory neurons suggests a role in
CC chemosensation. {ECO:0000269|PubMed:15953361}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=c;
CC IsoId=Q19084-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q19084-2; Sequence=VSP_018118;
CC Name=b;
CC IsoId=Q19084-3; Sequence=VSP_018117;
CC -!- TISSUE SPECIFICITY: Expressed in the pharyngeal neurons, MCL/R and
CC NSML/R and the AS group of amphidial sensory neurons, ASEL/R, AGSL/R,
CC ASHL/R and ASIL/R. {ECO:0000269|PubMed:15953361}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; FO080572; CCD83463.1; -; Genomic_DNA.
DR EMBL; FO080572; CCD83464.1; -; Genomic_DNA.
DR EMBL; FO080572; CCD83465.1; -; Genomic_DNA.
DR PIR; T15941; T15941.
DR RefSeq; NP_001024521.1; NM_001029350.4. [Q19084-2]
DR RefSeq; NP_001024522.1; NM_001029351.3. [Q19084-3]
DR RefSeq; NP_001033537.1; NM_001038448.2. [Q19084-1]
DR AlphaFoldDB; Q19084; -.
DR SMR; Q19084; -.
DR STRING; 6239.F01E11.5c.1; -.
DR GlyCosmos; Q19084; 1 site, No reported glycans.
DR PaxDb; 6239-F01E11-5c; -.
DR EnsemblMetazoa; F01E11.5a.1; F01E11.5a.1; WBGene00017157. [Q19084-2]
DR EnsemblMetazoa; F01E11.5b.1; F01E11.5b.1; WBGene00017157. [Q19084-3]
DR EnsemblMetazoa; F01E11.5b.2; F01E11.5b.2; WBGene00017157. [Q19084-3]
DR EnsemblMetazoa; F01E11.5c.1; F01E11.5c.1; WBGene00017157. [Q19084-1]
DR GeneID; 180970; -.
DR KEGG; cel:CELE_F01E11.5; -.
DR UCSC; F01E11.5c; c. elegans. [Q19084-1]
DR AGR; WB:WBGene00017157; -.
DR WormBase; F01E11.5a; CE38313; WBGene00017157; tyra-2. [Q19084-2]
DR WormBase; F01E11.5b; CE35711; WBGene00017157; tyra-2. [Q19084-3]
DR WormBase; F01E11.5c; CE30931; WBGene00017157; tyra-2. [Q19084-1]
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q19084; -.
DR OMA; NAHIEMF; -.
DR OrthoDB; 2877442at2759; -.
DR PhylomeDB; Q19084; -.
DR Reactome; R-CEL-390696; Adrenoceptors.
DR Reactome; R-CEL-392023; Adrenaline signalling through Alpha-2 adrenergic receptor.
DR Reactome; R-CEL-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR Reactome; R-CEL-418597; G alpha (z) signalling events.
DR PRO; PR:Q19084; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00017157; Expressed in larva and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; IBA:GO_Central.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR CDD; cd14967; 7tmA_amine_R-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF151; TYRAMINE RECEPTOR TYRA-2; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..468
FT /note="Tyramine receptor tyra-2"
FT /id="PRO_0000070223"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..387
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..410
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..424
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..444
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 252..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..126
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_018117"
FT VAR_SEQ 225..230
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_018118"
SQ SEQUENCE 468 AA; 53051 MW; 52868B370274AF79 CRC64;
MMSSYVMSPV DETYTLFQIL KGSALFLLVL WTIFANSLVF IVLYKNPRLQ TVPNLLVGNL
AFSDLALGLI VLPLSSVYAI AGEWVFPDAL CEVFVSADIL CSTASIWNLS IVGLDRYWAI
TSPVAYMSKR NKRTAGIMIL SVWISSALIS LAPLLGWKQT AQTPNLIYEK NNTVRQCTFL
DLPSYTVYSA TGSFFIPTLL MFFVYFKIYQ AFAKHRARQI YRQKLAVSSH VIRKHIESTI
LHEISHVLPT SDEFAKEEEE EEDSESSGQV ENGLGNGNDA IIEEDECEDE DSDEKRDDHT
SMTTVTATVT GPTEAPYMKR EAKISKSVPI EKESAIQKRE AKPMRSVMAI SYEKVKRHKN
RKERIYRKSL QRKPKAISAA KERRGVKVLG IILGCFTVCW APFFTMYVLV QFCKDCSPNA
HIEMFITWLG YSNSAMNPII YTVFNRDYQI ALKRLFTSEK KPSSTSRV
//
