ID Q1A5L2_DANRE Unreviewed; 1466 AA.
AC Q1A5L2; B0CM23;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=Crb2 {ECO:0000313|EMBL:CAP71968.1};
DE SubName: Full=Crumbs cell polarity complex component 2a {ECO:0000313|Ensembl:ENSDARP00000078813};
DE SubName: Full=Oko meduzy {ECO:0000313|EMBL:ABC46645.1};
DE SubName: Full=Protein crumbs homolog 2 {ECO:0000313|RefSeq:NP_001038764.1};
GN Name=crb2a {ECO:0000313|Ensembl:ENSDARP00000078813,
GN ECO:0000313|ZFIN:ZDB-GENE-060612-1};
GN Synonyms=crb2 {ECO:0000313|RefSeq:NP_001038764.1}, ome
GN {ECO:0000313|EMBL:ABC46645.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAP71968.1};
RN [1] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=9007238;
RA Schier A.F., Neuhauss S.C., Harvey M., Malicki J., Solnica-Krezel L.,
RA Stainier D.Y., Zwartkruis F., Abdelilah S., Stemple D.L., Rangini Z.,
RA Yang H., Driever W.;
RT "Mutations affecting the development of the embryonic zebrafish brain.";
RL Development 123:165-178(1996).
RN [2] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=9007246;
RA Malicki J., Neuhauss S.C., Schier A.F., Solnica-Krezel L., Stemple D.L.,
RA Stainier D.Y., Abdelilah S., Zwartkruis F., Rangini Z., Driever W.;
RT "Mutations affecting development of the zebrafish retina.";
RL Development 123:263-273(1996).
RN [3] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=10021342;
RA Malicki J., Driever W.;
RT "oko meduzy mutations affect neuronal patterning in the zebrafish retina
RT and reveal cell-cell interactions of the retinal neuroepithelial sheet.";
RL Development 126:1235-1246(1999).
RN [4] {ECO:0000313|EMBL:ABC46645.1, ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|EMBL:ABC46645.1,
RC ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=16713951; DOI=10.1016/j.cub.2006.03.058;
RA Omori Y., Malicki J.;
RT "oko meduzy and related crumbs genes are determinants of apical cell
RT features in the vertebrate embryo.";
RL Curr. Biol. 16:945-957(2006).
RN [5] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=17092952;
RA Hsu Y.C., Willoughby J.J., Christensen A.K., Jensen A.M.;
RT "Mosaic Eyes is a novel component of the Crumbs complex and negatively
RT regulates photoreceptor apical size.";
RL Development 133:4849-4859(2006).
RN [6] {ECO:0000313|EMBL:CAP71968.1}
RP NUCLEOTIDE SEQUENCE.
RA Martin S.and.Wright.G.J.;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000078813}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078813};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [8] {ECO:0000313|Ensembl:ENSDARP00000078813, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078813};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [10] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [11] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=28882989;
RA Hazime K., Malicki J.J.;
RT "Apico-basal Polarity Determinants Encoded by crumbs Genes Affect Ciliary
RT Shaft Protein Composition, IFT Movement Dynamics, and Cilia Length.";
RL Genetics 207:1041-1051(2017).
RN [12] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=29141686;
RA Nagashima M., Hadidjojo J., Barthel L.K., Lubensky D.K., Raymond P.A.;
RT "Anisotropic Muller glial scaffolding supports a multiplex lattice mosaic
RT of photoreceptors in zebrafish retina.";
RL Neural Dev. 12:20-20(2017).
RN [13] {ECO:0000313|RefSeq:NP_001038764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RX PubMed=29368007;
RA Fu J., Nagashima M., Guo C., Raymond P.A., Wei X.;
RT "Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration
RT That Targets Specific Cone Subtypes.";
RL Invest. Ophthalmol. Vis. Sci. 59:505-518(2018).
RN [14] {ECO:0000313|RefSeq:NP_001038764.1}
RP IDENTIFICATION.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038764.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CU694480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU855942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ314736; ABC46645.1; -; mRNA.
DR EMBL; CU638819; CAP71968.1; -; mRNA.
DR RefSeq; NP_001038764.1; NM_001045299.1.
DR STRING; 7955.ENSDARP00000078813; -.
DR PaxDb; 7955-ENSDARP00000078813; -.
DR Ensembl; ENSDART00000084378.5; ENSDARP00000078813.4; ENSDARG00000060106.6.
DR GeneID; 723994; -.
DR KEGG; dre:723994; -.
DR AGR; ZFIN:ZDB-GENE-060612-1; -.
DR CTD; 723994; -.
DR ZFIN; ZDB-GENE-060612-1; crb2a.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_000827_2_0_1; -.
DR OMA; WGIFCSG; -.
DR OrthoDB; 2877476at2759; -.
DR TreeFam; TF316224; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000060106; Expressed in retina and 22 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0032991; C:protein-containing complex; IPI:ZFIN.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045176; P:apical protein localization; IGI:ZFIN.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
DR GO; GO:0098609; P:cell-cell adhesion; IDA:ZFIN.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IMP:ZFIN.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:ZFIN.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IPI:ZFIN.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IPI:ZFIN.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEP:ZFIN.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IMP:ZFIN.
DR GO; GO:0021591; P:ventricular system development; IMP:ZFIN.
DR CDD; cd00054; EGF_CA; 18.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 11.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 18.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 13.
DR PROSITE; PS50026; EGF_3; 19.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q1A5L2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1403..1426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..69
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 97..134
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 136..172
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 174..210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 250..286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 288..325
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 327..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 365..417
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 419..455
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 457..499
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 501..541
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 545..732
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 734..772
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 778..959
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 961..997
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1025..1199
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1201..1237
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1239..1274
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1276..1312
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1316..1353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1355..1391
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 124..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 162..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 238..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 276..285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 353..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 407..416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 445..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 531..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 705..732
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 762..771
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 987..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1227..1236
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1243..1253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1264..1273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1302..1311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1343..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1381..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1466 AA; 161001 MW; CCAD2CDA1F58CE69 CRC64;
MEIRKVHLKG PGTVLLTMMM FKWGIFCSGS SDLCASSPCQ NGATCVDTMD DYVCLCSREG
VRYMGRDCEE LYNACMFAEC EGCESELGTD HYTCPEDKDE CKSGPCVGPH SECVNEQNGY
KCLCPPGFGG EDCSHRITDC IDEPCLNNGT CRRIVDGFEC ACSDGFRGET CEEDLDECDS
HPCQNGAICL DGVNKYQCFC VPGYQGHNCE IDINECASRP CWNNGTCING KDRYLCDCLL
GYTGVNCELE IDECESNPCQ NGATCHDLVG LYTCDCVQGF EGSDCEINID ECESGPCQNG
GLCHDRIDSY ECECEGTGYM GDHCEEDIPE CASHPCQHGG TCLEGINHYN CSCWPGFEGG
NCEVDIDECA DAPCENDGEC FEKSNPEHWE TDWEFTYATA VGYVCQCQPG YTGENCSVNI
NECVSEPCHN GGSCKDLVNG YMCECPEGFT GVECEVNIDE CESAPCLNGG VCEDGVAEYK
CHCAEAEEGL LPWGGPQCTV QLLGCIGHEC QNGATCLPWL DGETHGHTCL CPPGFYDDVC
SIQTTFSFSS PRFFLIELPS LERRRRETEP EHPLGVRLRF RTTLPDMLLF FRGNAEFFLS
LEIVGGELRA RATSKEEGSL EAQLPGLVSD GDWHEAIVNI NEHDIRLVLQ VKGANCNNQA
CRVEDKLQDG HETFLHHDSL TKVYVGGVPE EYIGLTLSGQ GFLGCMEDLQ VDGHPVLPHD
LGHEEESVEL GCVKTEWCQE DPQPCSQQGH CVDLWTSYRC DCYRPHYGQD CSKDMPTWTF
GHENSTSFLA FELLSDFGSN FSVSFFLRSL KSSGLLFQLR RSGVQGTEDE PYFTIYLEMG
RLQVTSMAES PILSSPVFVS NGEKPLLQVD IQDGQVFFNH GGYRYGLGLL PDLEVLEGDL
LYIGGVPGEE GATVWGGHFK GCLQDLRLDD VHLDVEDWNN TLSESIYIAS DSENVLPGCT
SDDTCKMEPC LNGGACTVTW NDFICSCPKD FTGKTCETRV WCVSDPCING GHCVDLLDGF
ECIANATFDN TPLHYSAKGS LLDPVTNVTM KLRTRQENGV LLRAWRGEEL LLIGLLDSSI
HVEIHTANSV EPVKFSGQRR IADGNWHRLL FAMAHPEHDA SQWFVLVDGI IDGSSAPVLA
GSLNFLKDIS SEVALAETFT GCLGAVRVGG VYLPFVDNTK SPQTTRFWRR PDEHVHLGCF
GAPVCRSHPC RRGGTCVDLF NKFGCKCPSG WEGNICEKEI DECISGPCLH GKCKDKLNGF
DCLCHPGYAG PTCSENIDDC KGSRCKNGGT CVDGVNDFTC ICPPKYSGTR CQYNYPPLKC
ALDVECENDG VCHDTPWGAN CTCPPGFTGE RCEREIDECA SSPCLNGGSC LDRLNRFQCL
CPAGFSGQFC ETNKQAQQDH IPWLAIAVPL ACGCILLVAI GLIFMLMTAR KKRQSEGTYS
PSHQEVAGAR LEMDSMLKVP PEERLI
//
