ID Q1CW70_MYXXD Unreviewed; 1040 AA.
AC Q1CW70;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Efflux transporter, HAE1 family, inner membrane component {ECO:0000313|EMBL:ABF91182.1};
GN OrderedLocusNames=MXAN_7240 {ECO:0000313|EMBL:ABF91182.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF91182.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF91182.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP000113; ABF91182.1; -; Genomic_DNA.
DR RefSeq; WP_011557159.1; NC_008095.1.
DR AlphaFoldDB; Q1CW70; -.
DR STRING; 246197.MXAN_7240; -.
DR EnsemblBacteria; ABF91182; ABF91182; MXAN_7240.
DR GeneID; 41364406; -.
DR KEGG; mxa:MXAN_7240; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_7; -.
DR OrthoDB; 9759330at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1040 AA; 112283 MW; 06936EE1419BB2B0 CRC64;
MFTDFFIRRP VFASVVSIII TLVGAISIPI LPIEQYPDLS LPVVQVTATY IGASAETVES
AVTTVLERQL NGVEGMRYIS STSSNTGVST ITVTFDPGRD LDIAAVDVQN RVATASAQLP
AAVNALGVTI TKAQTQLLMA FGLFDEENRY ETGFLSNYAD VFIRDALLRV TGVGDVRIFG
ERRFAMRLWL DPSELARRGL AATDVVNALR AQNVQIGAGQ VGQPPAPPGQ TYQFTVRVLG
QLTSAEEFGN IVVQQGPDGS LVRLKDVGRA ELGAENYGQL LRFNGREAVG LGIFQLPGSN
ALDVRDGIVA ELKRLKGNFP PGMRYQRAFD TTAAVQASIE EVLVTLGEAI FLVVLVIFIF
LHGWRSVLVV ATTLPVSLVG TFLFVNAFGF SINTLTLFGL TLATGLVVDD AIIVIENVER
TMEQDDVGPR EATHRGMKQV AGALVAIALV LSAVFVPVSF FPGTTGIIYR QFALTLAFSI
SLSALVALTL SPALCAILLR PHEGQKWKVF RMFDRGLDAF RDAYGRMLAK LIGPLRWPVV
IAFVVCLAGT ILVYRLTPTG FIPGEDQGYL IIAVQGPEGT SLDYTRNVLL QAEDVLRQQP
EVADIFTVGG FSLLGTGVNY GTLFVNLHPW DERKRPDQSV AGLVERLRHP LMAIGGARVL
PFEPPAIRGV GSVGGFEFVL EDQQGGRTLA QLAQTTDMLV GAASQDPGLR GVFSSYTANT
PLLDVQVDRE KALAMGVPLD GVFSTLQVYL GSQYVNDFTF ASRVYRVYVQ AAVPFRNEPR
DIDALYVRSA KGEMVPLESL VQVRPITSAQ NIQHYNLYRS ATINGQAAPG SSSGQALDTM
EAVARKTLPV GYTFEWTGLS QEQKEAGRSV LLIFGLGVVF VFLVLSAQYE SFALPLVILL
GVPVAMLGAL GLQNLRGLQN DVFCQVGLVM LVGLASKNAI LIVEFAEQLR HEGRSVEDAA
IHAAQTRLRP ILMTSFAFLM GVVPLMLASG AGASARKSLG TTVFGGMLLS TFVNLIFIPV
LYVVLEAARL RVRPPKPHAP
//
