ID Q1D120_MYXXD Unreviewed; 671 AA.
AC Q1D120;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABF91812.1};
GN OrderedLocusNames=MXAN_5510 {ECO:0000313|EMBL:ABF91812.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF91812.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF91812.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01251};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine.
CC {ECO:0000256|HAMAP-Rule:MF_01251};
CC -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000256|HAMAP-
CC Rule:MF_01251}.
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DR EMBL; CP000113; ABF91812.1; -; Genomic_DNA.
DR RefSeq; WP_011555468.1; NC_008095.1.
DR AlphaFoldDB; Q1D120; -.
DR STRING; 246197.MXAN_5510; -.
DR EnsemblBacteria; ABF91812; ABF91812; MXAN_5510.
DR GeneID; 41362764; -.
DR KEGG; mxa:MXAN_5510; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_018288_2_0_7; -.
DR OrthoDB; 9803479at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR HAMAP; MF_01251; UPF0313; 1.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR022946; UPF0313.
DR InterPro; IPR024560; UPF0313_C.
DR InterPro; IPR013704; UPF0313_N.
DR NCBIfam; TIGR03904; SAM_YgiQ; 1.
DR PANTHER; PTHR32331; UPF0313 PROTEIN YGIQ; 1.
DR PANTHER; PTHR32331:SF0; UPF0313 PROTEIN YGIQ; 1.
DR Pfam; PF11842; DUF3362; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF08497; Radical_SAM_N; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01069; UPF0313; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01278; MTTASE_RADICAL; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|HAMAP-Rule:MF_01251};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01251};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01251};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01251}; Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_01251}.
FT DOMAIN 321..592
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 613..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 335
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
FT BINDING 339
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
FT BINDING 342
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
SQ SEQUENCE 671 AA; 75234 MW; 260B62C8541B9827 CRC64;
MAHSTRYAHP FLPTTRADMQ ARGWEQCDII IVTGDAYVDH PAFGPVLIAR FLEGRGFKVG
LLPQPDWHSA EPFKALGPPR LFFGVAAGNL DSMLNRLTAQ KKNRSEDQYS PGGQTNCRPD
RATIVYAQRC REAYPDVPII LGGIEASLRR IAHFDYWSEK VRRSILFDAK ADLLVFGMGE
RPIMEVADRM RQGERIQDIR DVRGTAYTIN DEEMRALEAD PARRAADRKT VVLPSYEQVI
EDKHAFAVMS RDFQMETNPG NARPLAQRHG NRAIYMNSPA LPLEDGVGTA GAEGKSVAMD
ELYDLPFNRV PHPMYRERIP AYETVKHSIV LMRGCFGGCT FCSITEHEGR VIQSRSAESV
LREVRALRRM GDFRGTITDL GGPTANMYKL KCKSEDIEKR CRKLSCVHPG VCENLQTDHG
PLISLMQDVR KEDGVKHVFI ASGVRYDLAE RSPEYVKELA AHHVGGQLSV APEHVSPRVL
EKMKKPGIES FERFQQMFAC ASEEAGKEQY DIPYFISGHP GSTLEDMVEL ALWLKQNGKR
PRQVQDFIPT PMAMATAMYF TGLDPLKMEP VYTAQGLREK RLQKALLLYW NPEQWPLARE
ALKLAGREDL IGRGPHALVP PESPGEAARR QRTERDTGAG ASAPRHEAAP RLGPHGTARP
RARRPGGPRA R
//
