ID Q1D204_MYXXD Unreviewed; 402 AA.
AC Q1D204;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE SubName: Full=Bacterial leucyl aminopeptidase {ECO:0000313|EMBL:ABF89324.1};
DE EC=3.4.11.10 {ECO:0000313|EMBL:ABF89324.1};
GN OrderedLocusNames=MXAN_5166 {ECO:0000313|EMBL:ABF89324.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF89324.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF89324.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR036685-1};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR036685-
CC 1};
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DR EMBL; CP000113; ABF89324.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1D204; -.
DR STRING; 246197.MXAN_5166; -.
DR EnsemblBacteria; ABF89324; ABF89324; MXAN_5166.
DR KEGG; mxa:MXAN_5166; -.
DR eggNOG; COG2234; Bacteria.
DR HOGENOM; CLU_025866_2_1_7; -.
DR OMA; GMLQQDM; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR012189; Pept_M28E_Ap1.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR PIRSF; PIRSF036685; BacLeuNPeptidase; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:ABF89324.1};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR036685-2};
KW Hydrolase {ECO:0000313|EMBL:ABF89324.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR036685-1};
KW Protease {ECO:0000313|EMBL:ABF89324.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Zinc {ECO:0000256|PIRSR:PIRSR036685-1}.
FT DOMAIN 192..384
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT BINDING 211
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-1"
FT BINDING 226
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-1"
FT BINDING 261
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-1"
FT BINDING 288
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-1"
FT BINDING 366
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-1"
FT DISULFID 333..337
FT /evidence="ECO:0000256|PIRSR:PIRSR036685-2"
SQ SEQUENCE 402 AA; 42761 MW; EE4E96CC54E5011B CRC64;
MPVSLLLLNA PLALAEPLKA KPTDKTVWIA IGTDAITPMQ ETFAAEGWNV PTALKQQKHA
GVFQLKESQL SRLALMMHEK FDRCAGFITY ETQEEALASL APVAPNAAQK AVSYTLTNAA
TVNTLVGELS AANIRTTIAD LSAFPTRSQS SQGGVDAAAM LLAKWQGYVT GAGRTDVTVA
YYPHTGWRQP SVILTIPGTD LSGEVVVVGG HLDSISSTSA APGADDDASG IATFTEVIRA
AMARNYRPQR TVKFMAYAAE ETGLRGSREI ALSHKNNNIN VVGVMQLDMT NYKHPNATSD
VGIVTDNTNA TQNQFIRDLI TTYVGVPFTN TTCGYGCSDH ASWHSQGYAA SIPFEGTVVQ
KNPNIHTPRD TLANSDSSAA HALKFSKIAA AYVAELAKGT AQ
//