ID MUTL_MYXXD Reviewed; 619 AA.
AC Q1D568;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MXAN_4026;
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622;
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000113; ABF90814.1; -; Genomic_DNA.
DR RefSeq; WP_011554035.1; NC_008095.1.
DR AlphaFoldDB; Q1D568; -.
DR SMR; Q1D568; -.
DR STRING; 246197.MXAN_4026; -.
DR EnsemblBacteria; ABF90814; ABF90814; MXAN_4026.
DR GeneID; 41361357; -.
DR KEGG; mxa:MXAN_4026; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_7; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..619
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000076700"
SQ SEQUENCE 619 AA; 65220 MW; AC6DF120DF82A75D CRC64;
MSRIARLSDV LINKIAAGEV VERPASVVKE LVENAIDAGA GTVRVELDGG GVDRIIVSDD
GHGMGRSDAV ACLERHATSK LRELDDLFHI DSMGFRGEAI PAIASVSRFT LHSAAANSEV
GTRVSVEGGG PPLVEDAPPR TGTVMTVEDL FFNVPARRKF LRRGDTELKH AEEAVVRLAL
AYPEVGFFAS HEGGTLFSSA ACPDDPRERI AAALGSTSHP HLFPVEERRL GVAVTGFAAS
PEFTFNNARG LYTFVNRRYI RDRGLIGTIQ RAYQDFLAAG RQPVVVLHID VDPRAVDVNV
HPQKQEVRFA DARGVQEALT AALSRMLRAA PWLGSGVEGA APQAGQPMDA AHYAHAVERF
LTRAQEAAWG GPLPTAMDAP GPGPGAPSLG PLGQGARPGA LPFAAAVGQA PAFGQAQPQL
NEAPPPGYFG ALRPLGMLGG RFHVCEGPGG TLVVMDPHAA LERARLTGYL RALESGKPPP
APTLFGTTLE LPVAAAKALV EGREALSRLG FDVEPFGGTT VALKTVPPGL EGADARSLLE
ALARALPPKS ATLDTVSLAE AVRVMACHAA KQAGAVPLSD AQFRALLGEL DRADFHPTCS
HGTVVVLEMP LLELERRAR
//
