ID Q1D5E5_MYXXD Unreviewed; 420 AA.
AC Q1D5E5;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Polyketide TA biosynthesis protein TaC {ECO:0000313|EMBL:ABF90176.1};
GN Name=taC {ECO:0000313|EMBL:ABF90176.1};
GN OrderedLocusNames=MXAN_3948 {ECO:0000313|EMBL:ABF90176.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF90176.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF90176.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000113; ABF90176.1; -; Genomic_DNA.
DR RefSeq; WP_011553958.1; NC_008095.1.
DR AlphaFoldDB; Q1D5E5; -.
DR STRING; 246197.MXAN_3948; -.
DR EnsemblBacteria; ABF90176; ABF90176; MXAN_3948.
DR GeneID; 41361280; -.
DR KEGG; mxa:MXAN_3948; -.
DR eggNOG; COG3425; Bacteria.
DR HOGENOM; CLU_008065_3_2_7; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 1.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT DOMAIN 4..178
FT /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01154"
FT DOMAIN 279..371
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
SQ SEQUENCE 420 AA; 45499 MW; 9BE2B1B7DD0EE9F6 CRC64;
MGPVGIEAMN AYCGIARLDV LQLATHRGLD TSRFANLLME EKTVPLPYED PVTYGVNAAR
PILDQLTAAE RDSIELLVAC TESSFDFGKA MSTYLHQHLG LSRNCRLIEL KSACYSGVAG
LQMAVNFILS GVSPGAKALV VASDLSRFSI AEGGDASTED WSFAEPSSGA GAVAMLVSDT
PRVFRVDVGA NGYYGYEVMD TCRPVADSEA GDADLSLLSY LDCCENAFRE YTRRVPAANY
AESFGYLAFH TPFGGMVKGA HRTMMRKFSG KNRGDIEADF QRRVAPGLTY CQRVGNIMGA
TMALSLLGTI DHGDFATAKR IGCFSYGSGC SSEFFSGVVT EEGQQRQRAL GLGEALGRRQ
QLSMPDYDAL LKGNGLVRFG TRNAELDFGV VGSIRPGGWG RPLLFLSAIR DFHRDYQWIS
//
