ID Q1D5G0_MYXXD Unreviewed; 5150 AA.
AC Q1D5G0;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Mixed type I polyketide synthase-peptide synthetase {ECO:0000313|EMBL:ABF92489.1};
GN OrderedLocusNames=MXAN_3933 {ECO:0000313|EMBL:ABF92489.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF92489.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF92489.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
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DR EMBL; CP000113; ABF92489.1; -; Genomic_DNA.
DR STRING; 246197.MXAN_3933; -.
DR EnsemblBacteria; ABF92489; ABF92489; MXAN_3933.
DR KEGG; mxa:MXAN_3933; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG0604; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_223515_0_0_7; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 4.
DR CDD; cd08251; polyketide_synthase; 1.
DR Gene3D; 1.10.1240.100; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 453..874
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1788..1865
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1917..2354
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2858..2935
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2989..3426
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4356..4433
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4501..4938
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2950..2985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4334..4354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4463..4503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4334..4352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4468..4482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5150 AA; 552618 MW; D6197A448D8CA389 CRC64;
MGEGHRIGVL QQPPRGRDCH EADDGSRRIP QPPVPQVGRP GRGAVMTRLE ILQALQSGRM
ALADAKKALA AIEAQVQPED FGLVVAGVGG VEAARLSAWA VAPPSPGDIT IQVRASALNY
PDVMCVRGLY PTMPEYPFVP GFEVAGVVSA VGPGVARFAV GDEVIAVTGP LLGGHASKVN
VPADNAVRKP ATLTFEEACS LPVVFSTVYY AFEMGKLAEG EHVLVQTATG GCGLMALQLA
HLKRCICHGS SSRDDKRKVL ERIGVPHVID YTGDFAPEIR NQTGGRGVDV VLNMVSGEAI
QKGIDSLAPF GRYLEIAVHA LKTSPKLDLS RLVQNQTLHS IDLRRVGFAG RLGAHRLLDE
MAAMASAGEI VPIVSRVYPV RKLQDALQYV SEGKHIGKVV LSHTAEEVVD RTEACIEAMV
RHRKRFESSA PSKPTVPVSP PEVRTERPVT QDMEPVAVIG MAGKFPRASD LAQFWQNIAR
GVDCISEVPA GRWSVAEHYD ADGNTPGKSY SKWLGVLEDA ESFDPLFFGI SPAEAERMDP
QQRLFLAACW HCIEDAAIRP SSLSDTRCGV FVGCGPTDYG RDLRGGDLNA QALMGGATSI
LAARISYLLN LKGPCLAIET ACSSSLVAIS QACDSLVLRN CDLALAGGVN VAFGPAMHIM
SSDAGMLSKD GRCFTFDARA NGFVPGEGVG VLLLKRLSDA VRDDDPIAGV IRGWGVNQDG
KTNGITAPSA KSQAALEREV YRRFGIDADT ISLVEAHGTG TRLGDPIEVE ALVESFREHS
ARKHYCALGS VKSNIGHLMT AAGVSGVLKV LMAMRHQSLP PTLHFEAVNP HLALEGSPFY
VNTELKPWTG VPVRRACVSS FGFSGTNAHV VLEEAPSQSR TVAGDAVSPA APVVFTLSAR
TEVQLKELAQ SMAAFISATP DVDLRDLTYT LQVGREMLEH RLAILAGSRE ALQEALAAYL
SGRPSAAVLS GQAKRTAASI SALAADEDGR VLFESWLHKG KLRRVADLWT QGVDVDWRRL
YATHTPRRLR LPGYPFSKKR YSPPVVEAQA VSTVRGGAVL HPLVHRNSSV LAEQRYSSTL
RGDAFYLADH QVNGRKVLPA AAYLEMARFA ASDAWADEAV GRIPVLRNMV WTSPLVVDDA
AEVGVALHAQ DAGRLTFEIH SAPDAAGERT VHCRGLAELQ ERVAPRHDLR RLEADCTLRV
LSREQCYETF ARLGLNYGPG HRALVRVRVG HGQALGEVEL PEHLVGDGRS FVLHPALVDS
ALQAVVGVLG DEGGTAPALP FAVEEVVVHG PCIPRMWAVV RSGTGEGMAR KLDVDLCDEQ
GAVRVSIHAL SLRPLPEQPS ASVATGLFQM EWVPRELPAG DAGTFEHRVV ILCGMQGVDV
AQLSSRLDGA ECVAVDASHA SVADRFLHAS AQLLGVLQRV TTSRLSGKAL VQMVAASGAD
LLLYGLSGML KTAALEDDKI VGQTVLLAHP ASSIDQMVEV LRNEARGLGS NSVRYDEGRR
LLATWKARST DAVATASWPD SGVYVISGGA GRLGLRVAEE IAQRARGASI VLVGRSAPTS
EVAARIERIA GTGTQVVYRQ ADVGDLTAVD ALVREVRSAF GPIKAVVHAA GLLRDRYLRD
KTSEELQAVA WPKVRGIVNL DLATRGEPLE LFLVFSSIAG AIGNIGQADY AAANAFMDGY
AAHRDALVRT GERAGRTLSV NWPFWEEGGM QVDAATAKRK VREWGLAALS STQAFDALYR
GLRTDAAQLM VLSGHLEAIQ RRLTLSEEGG AHRAATGAAR AVTIDDDTLR TQVRQVLMSV
VSKVLKIPFE ELDADAELKE MGFDSISLTD LAHQLAGEYR LDLAPTVFFE HPTINALVGR
LVSEHRPLLA ERHRGVAGPV ADTSPEDTLP TPPVSRRSGR RSPGFSPAAV AKVPGQREPV
AVVGMSGAFP GAPDLAAFWR NLAAGRDCIE EIPADRWNWR DYFGDPAAED NKTRIRHGGF
IEGVGEFDPL FFGISPSEAE IMDPQQRLLM THVWRAIEDA GHAPQSLAGS NTAIFVGTGN
TGYASLLERS GVAIKGSTAT GSVPSVGPNR LSYLLDLHGP SEPIETACSS SLVAVHRALL
AIELGLCDAA LVGGVNTIVT PDAHIGFGKA GMLSEDGRCK AFARGADGYV RGEGVGVLYL
KRLSLAERDG DHIYGLLLGS AENHGGRANS LTAPNPKAQA DLIEAAWLRA GVDPRTAGYI
EAHGTGTSLG DPVEINGLKS AFHSLYEKTG AAEGTDAHIG IGSVKSNIGH LELAAGVAGL
VKVLLQMRHG VLAKSLHCEE LNPYIALKGS PFYVVQEGRP WLALKDASGR PLPRRAGVSS
FGFGGVNAHV VVEEYVPSHE ATPTPLRGPA ICVLSGRTEE QLRQQARQLH EAVEREGYRD
EHLPALAYTL QVGRDAMEER LALLVDSIAG LQEKLRAFVD GAGAGDAVFR GHVKRNKDAL
SVFTGDDDLQ EAIASWLSKG KYHKLLDLWT KGLSFDWNRL YGAQRPQRLS LPTYPFSRTR
YWVPEGEQPA GVPTWGALRA GGVDALHPLL RRNVSDLRQQ GYEAVFSADQ FFLADHVILG
KRVVPGVVYL EMARAALQLA EGEEAAVVRP VRVTNVTWPQ PQVVEGPTTE LRVSLFPEDD
GRVRFDIHSG SDDTHVCHSQ GLVTFFEPKP AAAVDVAALK SQCQRGELSA EQCYQAFASL
GAAYGPGHRA LRAVYQGVDQ VLARLVLPEG LGSTVAPYVL HPSLMDAALQ ATIGLSAQES
PAPIGLPFSV DAVEVLAPCP PQLWVWIRNA AGSTAGGAVR KLDLDLLADD GQVCIRLKGF
LMRPVKELRA APAPRILAPA EEVDASPADA GPLGDPSSVR DQIRSVLITE VARAVKVSAG
DIEINTEFSE YGFDSISLTE FTSRLNHGYG LSLTPTLFFE LPTIAALSEH LAEKYRQNFD
RYMVVAKRGA DSGNTPAPTK AVGPKAEARR LRRMPRPSRS AEPLTYGNDE PLAVIGMSGR
FPMAEDLEAY WRNLRDGVDC IQEIPASRWD WREIYGDANQ EPGKTLIKWG GFIDGIDEFD
PLFFGVSPSE AELMDPQQRL LMTYVWLAME DAGYSASSLS GTRTALFIGT GQAGYGSLIE
QANAEIKSYA STAAVPSVGP NRMSYFLNIK GPSEPIETAC SSSLVAVHKA MLAIHRGECD
TAIVGGVNTL PTPAGHIGFD KAGMLSPDGR CKTFSDQANG YVRGEGVGML MLKRLSLAEA
DGDHIYGVIR GSAAGHGGRT NSPTAPSPKS QAELLHATYT QAGIDPRTVT FIEAHGTGTS
LGDPIEIDGL KSAFTALDPT LGAGPVDRAF CGLGSVKTNI GHLELAAGVA GVIKVLLQMK
YKTLAKSLHS EQLNRHIRLD GSPFFIVRET QPWPALEDGA GNVVPRRAGV SSFGIGGVNA
HVVVEEYLPS SAPAAEVPQD APHLIVLSAK NEARLIERAR QLLHAVEQGE VSQADLPSVA
YTLQVGRDAM EERLGLLARS LEELKEKLLE FTEGRGLADS VYRGHVKRHK EFLSVFADDA
EMQEAVAKWM ARGKLSKVLE VWTRGMPVDW AKLHGGAQLR RRSLPTYPFA KEKYWVAKPA
RAENRVRAGS RAALHPLVHE NSSDLRGQRY SAHLTGEEFF LRDHVVGQDK VLPGVAFLEM
ARAAVVNASG LTPPGKVTLR NVVWSRPIIV TDAPVQVHIG LEAEQDGSVV FEIYGGTDEA
PLLFCQGRAR IGAGTDEEAT APCVDLSVLQ SGCQDRRQSG AAVYQTFASA GLTYGPTLRA
LQELSVGRGQ VLARAVLPEQ VLSSQGQFVL HPSLLDAALQ AALGLHSDEG GQLSLPFALD
ALEVWDGPAP SDVWIHLRDE TDGAAGKNRQ KISISLCDRD GKVWVRLKGF STRPVPAAGV
RAGAENHVLL FAPIWEETAL ASAPITAARR RVLVFCGATS AVAEAAANRI QGAQKVVMGT
SAASAPERFR ELVQKLFEAI KGMALQAGRE ATLLQCVVST QDTERDSLRG LLGLFKTARL
EHPTLQLQMV EVDAPTDVER VVARLQSSST APELPHLLFQ DEKVLVTRWR ELTAPAPEAP
LWRKGGTYLI TGGAGGLGKR FAQTIVEATE QASIVLTGRS PAGDAQRAFM ESLRRPGVRV
EYRPCDVTRA EDCQALIAWV RDTFGGLNGI LHAAGVIEDS LLKNKDWEAW ERVLAPKVQG
LTCLDEASRS ERLDFFVMFS SFAGAIGNPG QSDYAAANAY MDAYARQREA RVARGERFGK
TLSINWPLWR EGGMHVDAAT EQMMTHATGM AVLETTAGVQ AFQHALEHAQ SQVMILAGQA
ERIRKWLGRS GLLEGTSVSP SPSASATSST AEPGDEVRAR VSAMLCSEIA VVLKVDAAAV
DADSELSEYG FDSITLTEFA NRLNRAYELD LTPPVLFEYP SVDTLAGYLL RAHRESMVHH
FGEQERGATP EVVSLAERMP AAEPVTSALR TRERRGGSRG RSVEPARTDA PSTSTPARRG
PTPLAVVGMS GCFPGARDLE QFWTNLAGGV DSITEVPASR WDWRELYGDP RKEGNKTKVK
WGGFIEGVEE FDPLFFGISP VEAEVMDPQQ RLLMMHVWRA IEDAGYAPHS LSGTRTGIFV
GTGITGYNSL VERANLAIQG YSSTAVVPSI GPNRMSYLLN LHGPSEPVET ACSSSLVALH
RAMEAIDSGS CDMALAGGVN TIVTPGGHIA FDKAGMLSED GRCKTFSATA NGYARGEGVG
VVFLKRLADA ERDGDPIYGV IRSSAENHGG RANSLTAPNP NAQSQLLQDA YRKADIDPRT
IGYVEAHGTG TELGDPVEVN GLKSAFAAQI EARGGGTSLE KHCGLGSVKS NIGHLELAAG
MAGVIKVLLQ MKHRMLVKTL HCERLNPYIK LEDSPFFIVQ QTQDWPALMD ERGQPLPRRA
GVSSFGFGGV NAHVVMEEYL GNARANAAKA DVPRGPVAIV LSAKNAERLR EQAAQLLDAV
RSGRWSDAEL PSLAYTLQVG REAMEERLAM VVDSLAALET RLQVFLTGGR EGLFVGGRAG
RAHPSGKGSA EAEAAVRDAV TAWKAGDASP LLGLWATGGT VDWTQLYAAP LSRTHVPAYP
FARERYWISP APPREQQTLE KPVAQTRPSL IGQLRTRIGA AAIEGETVND
//
