ID Q1D6A2_MYXXD Unreviewed; 5741 AA.
AC Q1D6A2;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Non-ribosomal peptide synthase {ECO:0000313|EMBL:ABF91141.1};
GN OrderedLocusNames=MXAN_3634 {ECO:0000313|EMBL:ABF91141.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF91141.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF91141.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000113; ABF91141.1; -; Genomic_DNA.
DR STRING; 246197.MXAN_3634; -.
DR EnsemblBacteria; ABF91141; ABF91141; MXAN_3634.
DR KEGG; mxa:MXAN_3634; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_18_1_7; -.
DR OrthoDB; 5349841at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.20.20.30; Luciferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR024011; Biosynth_lucif-like_mOase_dom.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR011251; Luciferase-like_dom.
DR InterPro; IPR036661; Luciferase-like_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR04020; seco_metab_LLM; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00296; Bac_luciferase; 1.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 6.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF51679; Bacterial luciferase-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT DOMAIN 619..695
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2034..2109
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3094..3168
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4572..4647
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5630..5706
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 5706..5741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5707..5727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5741 AA; 623307 MW; 10253558FC1C20C9 CRC64;
MLRVPPQRRS PAFPQLHPLE PLTMRSHPAA TLLELLETQT QSLGERRLYT FLEDGGDDAV
LSYAGLDLRA RRIGAALQAL ARAGERAVLL YPPGLEYVAG FFGCLYAGLV AVPAYPPDPM
RLERTLPRLR AIIRDARASV VLTTSFIQEM GEGLFEGAPE LAALRWVATD ALPEGTEAGW
RRPEPSRDTL AFLQYTSGST GDPKGVQLSH GNLLHNLGLI SHAFQVRSDS VGVIWLPPYH
DMGLIGGILQ PLYAGFPVAL MSPLAFLRRP RFWLESLSRF GGTISGGPCF AFDLCVRKVP
PAEREGLDLR RWELAFCGAE PIRPEVMTRF SEAFAPVGFQ REALYPCYGL AEGTLIASGG
RKGEGVLTRM WDAQALERNE ALAAEDGPGA RPLVGCGQTL PEQTLLVVDP ETRRACPPER
VGEIWVSGPS VAHGYWERPE ESEAAFGARL ADSDSGPRFL RTGDLGLLKD GELFVVGRRK
DLIILRGRNL HPQDLELTLE RSHSALRPGC GAAFSIDVGG EERLAVMYEV DSRKPWTAED
VVGAVRRGLA ETHEVQLHTL VLIEPGALPK TSSGKIQRRA CRAELLAGTA RALLTWSESE
ADAPQAKAPA PDITASQPLT VEALEAWLLA RIASRLRVRP EELATDAPIT SFGLDSLGAV
ELANDVETLG VVLRMEVLLQ GPTVGALALT LFAARGASTG AELTRGEERT PAPLSSAQQR
LWLFEQLAQG SAAYHLPAAV RLTGALDDVA LEHAFAAIVQ RHAALRATFR DEDGTPSQVT
SSVPVSSLRR VDLRDVPVDA REEAALRLAH EEARAPFDLE RGPLLRATLF QLDAHEHLLV
VVMHHIASDG ASFAILAREL SALYAGDVSL PPLAFQYPDF ARWRREVEAD GALATSLDWW
KARLAGGAAA LELPADRSRP PMPSYRGGRV AVRFPEALTA RLEALGRSEG ATLFMTLLAA
FEVLLARHSG QADFCVGTAV NGRERAGLEG LMGCFLDLIV LRASVSGSSR FRELLGQTRE
GVLAAFAHRG VSFERLVDAV QPTRDPSRAP LFQVLFVLQP EPGAGLALPG LESRRVEVDP
GATPYDLTLS LARGPEGLGG WLEYATDLFD ADTAARLVAR LGVLLESIVA DPDQRLAMLP
LLPEAEQRQV LVDWNDTRAE FPEACIHALV ELQAQRTPDA VAVVCGDGVL TYRELNQRAN
AVAWRLREQG VGPECIVGLF ADRSADLVVG LLGIFKAGGA YLPLDPSYPE ARLALMLEDS
GASVVLAHRH LAGALPFGDR TVVPLDVAGE ADAAPPGAVG PDNLAYVLYT SGSTGKPKGV
LIPHRNVVSF FTGMDARVGT EPGTWLAVTS VSFDISVLEL LWTLARGFKV AVQGEQGALG
AAPRRVTRSR QKPLGFSLFY FAADEGAPGA ERYRLLLEGA RFADRHGFQA VWTPERHLHA
FGGLYPNPSV TSAAIAAITE RVAIRAGSVV LPLHHPVRVA EEWSLVDNLS KGRVGISVAP
GWHADDFVLA PERYAERREL ARRDLDTLRR LWRGESLSFP NGAGTPIDVR IRPSPVQREL
PVWLTAAGNP DTFREAGRLG AGVLTHLLGQ RWEELESRIA LYREAWREAG HEGEGHVTLM
LHTFVGHDVE RVRETVEAPL RRYLSNSADL MRGLGRTLGV DLDPASVRPE DLDALVGRAF
GRFFDGAGLF GTPRTCREQV ARIEALGVDE VACLIDFGVD TDAVLASLPA LDAVRQRCER
DFRLQSQEEI TVPAQLRRHG VTHLQCTPSL AQALLLEPGA AGALVGLERL LVGGEALSAE
LAERLRGTMG GALLNMYGPT ETTIWSSSHA VDGSPGPVPI GTPIANTSLY VLDAELRPLP
VGVPGELYIG GMGVARGYHA RPELTAERFL PDPASSNAGA RMYRTGDRAR WRADGTVEFL
GRVDHQLKVR GFRVEPGEIE SVLARHSDVA QAVVVAREAS AGGARLVAYV VARPGTALSV
EALLAFSRRS LPEHMVPSAF VPLDALPLTP NGKVDRKALP APEGVRDVAR EYVAPRTDTE
RRLAELWASL LGVERVGAED DFFALGGHSL LATRAASRIR EAFGVDLPLR ELFESSSPAA
LGARIDARLL GASGVPPLVA RSHEGALPLS FAQQRLWFLE QLEPGGAAYN DAVAVRVEGA
LDVALLERSL REVVRRHEVL RATFHDDGGT PSWRIHPEAR LALDRVDLTA LSGADQAEAL
SLRLAEESLR AFDLGAGPPL RATLLQVSAR EHVLLLVLHH LVTDGASMGV LVLEVAALYR
AFSQGQVSPL SPLPLQYVDY AAWQRDWLRG EALEAQLAYW RTRLGGAPRA LDLPTDRPRP
AVRSSRGVSR SMLLGPELSH ALKTLAQREG ATPFMVLLAG FSALLSRHGG QDDLCVGTPV
EGRDRTELEG LIGCFVNTLV LRVSLAGTPS FRELIGRARE TVLGAFAHQD APFEELVKAL
QPERDLGRSP LFQAMLVMQE DPLPELVIPG LRLNVQPQPS LTAKFDLRLI ITDTADGFSA
NLELSTDLFE PDTATRLLEH LRVLLEAGVR EPEQQVHALP LMTSAERHRV LVAWNDTDRP
RPGVSVLHRL IEARVDRTPD VVALSFESDT LTYRELDRRA NQLARYLRAR GVGPDTRVAL
CVERSLEMVV GLLGVLKAGG AYVPLDPEYP RERLEYMLAD AAAPVLLTQA RLSERLPRDS
ATVVCLDSEW DAVAREREER LDVTVDGSGL AYVLYTSGST GRPKGAMNTH AAICNRLLWM
QEAYGLDSSD RVLQKTPFSF DVSVWEFFWP LLAGARLVMA RPGGHREPAY LTDTIARERI
TTLHFVPSML RPFLEETELA VSCASLRRVF CSGEALPPEL RDRYFSCLLA ELHNLYGPTE
AAVDVTAWAC AREDRGHVVP IGRPIANARM YVLDARLRPV PAGVPGELYI GGAPLARGYW
QRPDLTAERF LPDAFAAQPG ARMYRTGDQA RFLANGAIEY LGRLDDQVKL RGFRIELGEI
EAVLSLHPGV RAAAVAIRED VPGDRRLVAY VVAPSGDVAS ELRAFLGERL PEHMVPSAFV
TLDALPLSPS GKLDRRGLPA PVRAVQGRGA AHVEPRNALE LEIAQIWAGV LGVERVGAED
RFFELGGDSI LALQVIARAR QVGIHLTARQ LFQHPTVAGL AQVATSRRRL GDQGPVVGPV
PLTPIQRWFV ERELPEAHHF NQALMLEPRE RLESDVLACA LRALVDHHDA LRLRLSRSDT
GWAQSCAEPG RDVPLRLVDL SGLDAAARAV AMERTATEEQ AGLDLNAGCL LRAVLFDPGP
NRRGRLLLVI HHLAADGVSW RVLLEDLETA LRQLARGEPV ALPAKTTSFQ AWARRLEVHA
ASGVLAEEGA YWRDVLSADV AALPRDVPGG VNSQGSERVV TVALDADVTH SLLRASATMS
QPGLEDVLLT GVASALARWS GERRLRIDLE GHGRDELFDD VDLSRTVGWF TALFPVRLEL
PEGLASASVL ASVRAAREHR KGRGVGYGLL RYLRHDAGAS SEVLFNYLGQ LDSGTRDSAL
FSLAPESTGA SQGTRGLRSH VLEVVARVVG GRLELAWHYS EALHSRARIE ALARHCVETL
VELAGATEEC HALSPLQHGL LFQVLLEPGT GAYFEQRSWT LAGPLNAGAL RRAWEAVSER
HSSLRTSFLW DGLEAPVQVV HARATPVWAE LDWRGRSSEE QSQSLAAFLR EDRAQGFVLS
QAPLMRLALI RLEDHAWRFV WSFHHLLLDG WSLARVLGEV LDAYAAIAAG ADWLPPAASM
DFRTYVEWLG RRRPEQDEAF WREQLEGIEA PTPLPAAGGS TAAHDTGEHA LDLGEADTAA
LQEFARSHGL TPSTLVHGAW ALLLSRYGGG QDVMFATTLA GRPPELPGIE EAVGLFIHSL
PVRARIQHGA GLLPWLSELQ SLLVELGQRE HVPLTRLQGW SDIPRGTPLF ESLLVFENYP
VDAALVRGAS GLELRDFAAF ERTHYPLTAV VVPGRSMRLK LLYRQERISK VAAEQLLTHW
RGLLQAMWSR PEQRLGDVSL LSEAERRRVL VEWNATATTY PREATVHSLF ESQAARAPET
VAVRYGGTSL TYAELNAWAN QVARRLGALG VRRGTHVGLC VERSAELVVG MLGILKAGAA
YVPLDPAYPR ERLAWMIADA GAPVLLTQER LRGAVPSEGV SVLTVEEVSA QGDVAETAAL
GAGVGAADAA YVIYTSGSTG TPKGVCVSHQ AVVRLVVETD FIRVVPEDRV AQASNASFDA
ATFEIWGALL NGARVVGVER ETALSPSAFA SWLREEGIRV LFLTTAWFNQ VAAEVPDAFS
GLRQLHFGGE AVDPRPVRRV LREGAPERLL HVYGPTENTT FSTWHLVTDV PEGAVSIPIG
RPLANTVQYV LDEDMAPVPP GGVGELWLGG DGLAWGYLGQ PALTAERFVP NPFSERPGTR
LFRTGDRVRL LADGAVTFEG RVDAQVKVRG FRVEPGEVEA ALLRHPDVRQ AVVLAREDEA
GGSRRLVAYV VPTAEAAATP EPSLLRTFLA AHLPAYMVPA AFMVLGRLPL TPNGKVDRRA
LPAPTVESEV IAPRGPEEEL LAQLFGELLG VSRVGASDSF FDLGGHSLLA TRVVTRIHAT
FGVALSLREL FDDPTVARLA GRIREARQSS GTARPPPIVP VSRDNPLPLS AMQERLWLLE
QLQPGTALYN VPWAAWLAGP LDVPALERAL AGLFLRHEAL RTTFSSNAGE PVQIIHPSAN
VALLVVDLEG LPEEAREAQA VIAASEEARR PFDLVNGPLC RALLIRTADD SHLLVLTLHH
IVSDGWSLGV AVRELSALYA AELQGRPSSL PVPTIQPADH AVWQRQWMQG EALAAQVGYW
RRQLAGAPPV LELPKDFPRP SLQRFRGDTL AVRFPAELSE AFRALCIREG VTPFMGLLAA
FQLLLSRVSG QEDVCVGSPI AGRQQPGLEN LIGFFVNTLV LRARLPRSSS FRELLRQVRE
TTLDAYAHQD VPFEKLVEAL QPPRSLSHAP LVQVVLALHE ASRQDVAPQG LALRPVELAS
GTAKFDLTLS LTDAAEGFTG TLEFDADLFT RETAARLMKG LRVLLESAVA DAGQRLGELP
MMDSADRQRL LVAWNDTAVE YPREACLAEL FEAQAARSPE AVAVVCEEAR LTYAELDRRA
NQLAWYLRNR GVGPGTPVGL CVQRSLDLVV GMLGILKAGG AYVPLDPTYP RERLAFMVED
TRLPVVLAQQ SVVALLPSGS ADVVLLDSAW DEIAREPTVS PRVTVPAESL AYVMYTSGST
GRPKGVCVPQ RAVARLVLGS RFARWGADEV FLQLAPICFD AATFEVWGAL LHGAKLVLFP
AQPPTVDTLK DVLARHGVTT LWLTAALFEA LSAARPDALD GVRQLLAGGD VLPPAAVRER
LGRGGILVNG YGPTEGTTFT CCHVMEGAVA PGAIPIGRPI ANTRVYVVDA ALRPVPVGVP
GELLIGGDGL AWGYQGRPEL TAERFVPNPF GSEAGGRLYR TGDSVRYRED GTLEFLERLD
GQVKVRGYRV EPGEVEEALR LHPSVAEAVV VARPDPAGGK RLVAYAVPRA GETLDPRGLR
GFLAESLPEF MVPSTLVPLM ALPLTPVGKL DRRALPEPEV SRPAGSAFVE PTTALERQVA
ALWAKVLGVE RVGVEDHFFA DLGGSSMSVV KACALLRDEL KRDVPATRFF EHPTVRAFVM
SLERDGETAA DTQDNEAHVD RAQQRRQAIR RQGRRGNHGN G
//
