ID Q1D6R4_MYXXD Unreviewed; 2216 AA.
AC Q1D6R4;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Polyketide synthase type I {ECO:0000313|EMBL:ABF89617.1};
GN OrderedLocusNames=MXAN_3462 {ECO:0000313|EMBL:ABF89617.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF89617.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF89617.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
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DR EMBL; CP000113; ABF89617.1; -; Genomic_DNA.
DR RefSeq; WP_011553495.1; NC_008095.1.
DR STRING; 246197.MXAN_3462; -.
DR EnsemblBacteria; ABF89617; ABF89617; MXAN_3462.
DR GeneID; 41360809; -.
DR KEGG; mxa:MXAN_3462; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_231431_0_0_7; -.
DR OrthoDB; 9803628at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd00586; 4HBT; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT DOMAIN 538..984
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1307..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2216 AA; 234476 MW; 045F07C10A493242 CRC64;
MGYFAVPYDI HFDDTMAYGS HHFLTNFKFQ CAGREHLLFS PDVFDVPEFR RDFDQVLLLT
YEGYSRNLAP ASLGDRLVVL TTLEEGGAVS IRFCFRTLKS DGTPVACGFQ TVLCADRTSG
ALCSFPDSFL RCFDSLSGIF ERAGARSFRD CVQQGGSALK EVFPESIRAL AKSLLADPAS
LGTSRVVSLE GAPAASTAES PGALVLPPGA TAFLFAGQGS FDPGLYLQLK ALDPDLGDEL
QGVAAACRAV GVEAEPLLAA RDVSGVQRAL EELPQLDQLG IYLSGVLGAR WMQRQGASPD
VFVGHSFGEI AAMTAAGALD LRAGAQVVCH RIRALQVLPD DFGTLAAVAL GESEAVRAIA
ECGASRLHIA GRNHARQTVV AGARGELARL RALLEGRGQG FTFVSSRYPF HHPGMAPAAK
AFREMLDRVP MQAPRRRIYS PIERRAYVGG RPELADALAS HLVRSFDFLG TVETLSRAGC
ARFVDCGTTG VLARIVQKII PEETAAEVSV ISKLLPAERS APSAGIEPKS VDAAEVDESG
IAVVSLGCIL PGGAKDPETY WQNIRKGISG IVDQGLLQPE LVTDFAGPAG TPDRTYTLLT
GYVRDEDLVP PPGFDPTRFQ QYVREQKLLA IALSQAMQGL KPVASKTPGR IQCLLGSTAE
GSAEYDAALS VEAGEALLSA RGERVHDIAA LACAAREALG VEAISSDLAP HPTLQAVVTD
VVGQGVATTL LDAACASSLY AMALGMKALE RGDSDLILAG GVFSPGPGNS CLFSQFNGLS
ATGSRPFDAR ADGVIFGEGA GVVGLMRLKD AVAAGHRVHA VIRGAGLSSD GRSSSANVPR
SDGQVAAMEA CYSGAQVDPA SVQYIEAHGT ATPAGDATEL RSIARVFGGK RSGVQLASVK
ALIGHVGWAA GAASVIKLCK AMAHRIFPVQ SNFDAPGAAL RAMGPGFEVN TREQPWPENG
ELPRRAATNG FGFGGTNAHL VLEEYRGPSS APKSREGIPS EAELVVVATE GLFPDGRGRP
EAGVPVEVGA RFDLQALRLP PTVRLLPDIS EDMDATQHLG LVVGSALAQK LGAFDALRSG
TAIVLGLEGK TRRGVEAVQR VLAFTLQRRL SEKARREPAS AAVLPLAERL YSAVMGSLRP
SGPYTLQGMM PNVTPGRVAG ALDVKGPNFV VDAGAASSSA ALQAARGLLE SGFELVLVGS
THIGRPGEVR GAQQPEEGAA LFAVTTAEKA RRLGLKPMCQ LQLSTRGTKG TGAGIDLPPH
SAAESLALLR AVHAAADGRA GTLRFHPDAA TGVRLEVRLQ PMADGLPVES MQSSSRAHSH
AATEGRLGVS SRAAEQGGRI DASTSPLRTH PDAVTDGRSE LPSRPSEGVR LASSRSVESA
SSPADGASGA ELQAAAGGFD HAAPIQYLSP VLVERPVRKT RPSYLRGRRV LFIAEDVALA
RELAARAQAL CGAEHLILCP GTGSDSGRVR YVDLTTDTSA EAGLAALGFE PEVILAVSRI
EAGALEAAVV ADTAMKHGAL ELLFLTARRA YERLSRGEVE LVSLCIGAVG PRRCLHPMSG
LFAGMLKSIG REVPARNVRA VSTTAMLLQE ALELAEAELG SEVEGNHSIE VCFEGPVRCV
RVLRVTDVTA DLAATLDSRS VVLLTGGGRG VTAVLAGALL KRFGCKVVLV GRSDPDEAPL
RVLQAREEDL PAMEREFYAS ELARNRGVRM PELRKRFERF LAARELKATL EGLGRLPGEV
LYRAADVTRA ADVDRVVQEI VDTHGRLDLV VHGAGTQTSK KLNRRQLGEL RTNLGTKLLG
LRNLREACVS RLARPVPFHI LTSAFSYIGN DGQADYGAAN EALDRLCAWV SDASQEVRWC
SVGWLAWDGI GMTRGSEYRV LGASRHLRGI RAEEGEALFL QLVDGRPRQA INVQLTESER
SYYALEVLPA EETRSLSAGP VQRELVVDSA SVPCLEDHLV RGTPTLPGAW ALDLMLQAAV
GNGRPELRTV TIEDVRFSRF IRVKQGGRQH LRAECSPLID EPGCHGVRVR LMGDIVHASG
VVLEKDLVYA EARFTLTAEP PRGTPELDAA APSGQALRVH DPHCAAGAPI ELRKMFDCLE
EIRIEPSARF ARLGLPAEPR QAGSTVPALV LDAALRLSAM HVDGESSAVF APIQFQRATF
DRGLVDVRGG APLHLSLKAL PPRVDGDLLE CGTVAALDEA GRLRMLLEGG LARPMA
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