ID Q1DA37_MYXXD Unreviewed; 255 AA.
AC Q1DA37;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN Name=rnhA {ECO:0000313|EMBL:ABF91338.1};
GN OrderedLocusNames=MXAN_2265 {ECO:0000313|EMBL:ABF91338.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF91338.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF91338.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the RNase H family.
CC {ECO:0000256|ARBA:ARBA00005300}.
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DR EMBL; CP000113; ABF91338.1; -; Genomic_DNA.
DR RefSeq; WP_011552341.1; NC_008095.1.
DR AlphaFoldDB; Q1DA37; -.
DR SMR; Q1DA37; -.
DR STRING; 246197.MXAN_2265; -.
DR EnsemblBacteria; ABF91338; ABF91338; MXAN_2265.
DR GeneID; 41359653; -.
DR KEGG; mxa:MXAN_2265; -.
DR eggNOG; COG0328; Bacteria.
DR HOGENOM; CLU_030894_3_0_7; -.
DR OrthoDB; 7845843at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd09278; RNase_HI_prokaryote_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR022892; RNaseHI.
DR PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ABF91338.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT DOMAIN 2..154
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
SQ SEQUENCE 255 AA; 27709 MW; AB75DA36A067A858 CRC64;
MEHRPTLVFA DGACSGNPGP GGWGSIIVTP DGLVTELGGH EPETTNNRME LTAVGKALRH
LERAPGPIHI HTDSTYVIQG ATKWAFGWSR RGWKTAEGGE VANAIYWKRL MALLAQRKES
HAAEAAAVAW FYIRGHVGVP GNERVDAIAV AYSKGRDARL YTGPLHGYGV AVHDLPEDMS
LPPEKPKEQR EAAAKAYSYL SQVGSSVKRH ASWAACERRV KGVSGARFKK TKSALDEAKV
LEDWGFKGQD VPSED
//
