ID Q1DC99_MYXXD Unreviewed; 693 AA.
AC Q1DC99;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=pkn1 {ECO:0000313|EMBL:ABF86229.1};
GN OrderedLocusNames=MXAN_1467 {ECO:0000313|EMBL:ABF86229.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF86229.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF86229.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP000113; ABF86229.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1DC99; -.
DR STRING; 246197.MXAN_1467; -.
DR EnsemblBacteria; ABF86229; ABF86229; MXAN_1467.
DR KEGG; mxa:MXAN_1467; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_009977_0_0_7; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035438; F:cyclic-di-GMP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 2.40.10.220; predicted glycosyltransferase like domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR009875; PilZ_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF07238; PilZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:ABF86229.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:ABF86229.1};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000313|EMBL:ABF86229.1}.
FT DOMAIN 59..328
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 630..663
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT BINDING 88
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 693 AA; 74287 MW; FD532EABF38A7CE6 CRC64;
MPEVSSGGGC GACGRRHGAD ASCPTLVRAD VRAGGTAHPR CAPVVEAQDP LVGVRCGSFR
LVRRLGRGGM GAVYLGEHVS IGSRVAVKVL HAHLTMYPEL VQRFHAEARA VNLIGHENIV
SIFDMDATPP RPYLIMEFLD GAPLSAWVGT PLAAGAVVSV LSQVCDALQA AHARGIVHRD
LKPDNIFLVR RKRNAPFVKV LDFGIAKLAD AHMPQTHAGI IVGTPEYMAP EQSLGRGVDG
RADLYALGVI AYQLLTGRLP FNDEGLAAQL VAHQLRPPPP PSSVYPAVSA ALEHVILRAL
AKKPEDRYAS IAAFRNALQV ALAEHVRVSA RKTRPGGLAV LERAPVAPDM PTEGQSRGRL
GVDARAGHVP SSLASTSQRR LAPAAPAVPR ASLVEVPVQV VLRPGESPVR LRGSGLSRGG
LFLHGGRVLP PLCSRLPVVL ELASGPLSVM CEVVRVVPPA QARVWGMPTG FGVQFVEATA
VLKAAVDALL QGEPVRAVPQ VPLTEDPAVA RLLEAWRQRS AGDAYAVLAL EPDSDMGTVR
LRTREAWRSL ESLEQHSLTP PQRAQVDALR VRVREAAEAL GATVQRALYD AWRGNHRGVA
KCLEAGLTAE QLESLRREFL ARRPQAMGTA RSHFQSGGAL ERDGQLSQAL DQYERGLKLA
PLEVDMLQRY RRLRRVLGGR ATAPTGHDRA RSP
//
