ID Q1DES0_MYXXD Unreviewed; 1572 AA.
AC Q1DES0;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=MXAN_0585 {ECO:0000313|EMBL:ABF86815.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF86815.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF86815.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP000113; ABF86815.1; -; Genomic_DNA.
DR RefSeq; WP_011550716.1; NC_008095.1.
DR STRING; 246197.MXAN_0585; -.
DR EnsemblBacteria; ABF86815; ABF86815; MXAN_0585.
DR GeneID; 41358064; -.
DR KEGG; mxa:MXAN_0585; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_002018_1_0_7; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1572
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004188223"
FT DOMAIN 668..815
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 881..973
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1572 AA; 168606 MW; B743FCE461089992 CRC64;
MKCLIRLAAL SALMLSGVAL AKPLYITVPR SYGTQEPVAV DVAFEDKGPV ELRVLKPENL
DAFIRAQGDL RRAYQTPPTL KNPGRALSRG FNAVRTPGMF LLDTLSPAFR DEVGEVLPRA
PQASGSGEPL AKVAEGPERL VGVPPGFTVT RSQWLNLDLG GAERDFNVPG FNASGSSGFQ
ERRVTLAPLP AGTYVLQLVQ GRVEGQVVLV VSDLTVQLKQ TDGQVLLRVA GRDQKPREGA
EVQVYLPKGK GPAGKTNAKG EVTLEVSEPR VIATATAGGD TAIVDTDFYS ALAVAPDVFI
YSDRPIYKPG HEVKFRGVVR QPDTFLARLF TPKKRQVQVK LVSQEGRALT TRAAVDEFGA
FHGTLKVPDD LGTGVLRVEA EVDGHPHQGE ARVQDYVKPT FYLEMEPASE TVVPGQTLRA
KVRARRYAGG TPDATKYEVF LYRSLLDAPA WVDDAGKGGQ GSDVTYGSAS TTEGKLSVPE
RLYSSVEARG AYEDPWSSAS AFDANGEAEI EVAVPALAAG EERLPYRYSL TVRARDDQET
FANATSAFFL SKVEVLGLAR YSDAVVAKSG DATLAIRATT LSGKPYGVTQ GEVEFVLRKA
DGSEKSLGKR SFSTAADGTH REKVPTSDVG SVLARVVVKD KNGETWQGEE SLLVIGGADE
PVARVPNLTL ASLSGTLAPG DTAKLVALMP DSWGSGGRDA GPVWVTLSGA SLYDTQVVEL
TGRTLVHSFN VEKRFGSAVY ASVAYPTATG RWEERTVAFR VIPRERTLTV ELQPRRAEAT
PLTEQSIDVR VVDHEGRGVV AQLSVGVVDK AVYAIQSEFR PRVLDFFYPP ARNNVSNFFS
SEFQGYGYGE ALARKMAGLP DHAFASIKPP SRQTKDLERD TAHWDPAVVT DRDGRATVRF
TLPSNQTLWV VTAVAADTSG RFGEGTSEFA TRGGLNLYAA LPQFLREGDE AVASVRLSAG
EKSPASQLLD VKLASLGALK ADQFEHKVEL AKGGEQVVPL TLKASSTGAA QLTVNVAGGK
DSLRDLKRFD VGPAAVEDVV KVSAWGGGAL EVPAPQEATL ARVELVLQPS IVDAALSNVR
ELLTYPYGCL EQLVSTTVPN VAVYQVLQKA GALAKLDTDT QALLAEARSR SVQGTARILD
MSVKGGGFTW FGGYETPSLP QTLIALDGLA YAAEAGLVDR ADPRLVESAR WLEAQEGLPP
EYEATRAYVL ARLEGSKQAA RVRALVQGAE GGDLYPLALA VLAAEKAGVI KEPALQTQIN
ALVARSAQGY ATLAALGPGQ SLEQSEAFFR FPLRRVGMTA IAAHAASFGT LDITRARRRI
LELLSEPDLS TFDRSTTLLH SLWLLERDAK AMQGMKAPEV KGVKTPVKFA PRGLGLVAVL
APGTRTVDVG GFDGVATLRA TTRTPLSAVQ PKAEGMSIQR AYYVLRESGK VRLGAGDTVS
QGEEVYVELT LDARGDNRVR SAYYVVEDAV PAGFVPLQED KAFRGPPHSL PLVPEALKRR
VLNPERATFF FEEPAWWSDS PRTVGYVLRA QFAGTFSAPP AHIEDMYAAS IHGRTAADSL
KVVPSKKHLG DL
//
