GenomeNet

Database: UniProt
Entry: Q1DR06
LinkDB: Q1DR06
Original site: Q1DR06 
ID   SET1_COCIM              Reviewed;        1271 AA.
AC   Q1DR06; J3K3Q9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   10-APR-2019, entry version 93.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=COMPASS component SET1;
DE   AltName: Full=SET domain-containing protein 1;
GN   Name=SET1; ORFNames=CIMG_07257;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC       specifically mono-, di- and trimethylates histone H3 to form
CC       H3K4me1/2/3, which subsequently plays a role in telomere length
CC       maintenance and transcription elongation regulation.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC   -!- SUBUNIT: Component of the COMPASS (Set1C) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; GG704912; EAS31778.3; -; Genomic_DNA.
DR   RefSeq; XP_001243361.1; XM_001243360.2.
DR   ProteinModelPortal; Q1DR06; -.
DR   SMR; Q1DR06; -.
DR   EnsemblFungi; EAS31778; EAS31778; CIMG_07257.
DR   GeneID; 4562336; -.
DR   KEGG; cim:CIMG_07257; -.
DR   EuPathDB; FungiDB:CIMG_07257; -.
DR   eggNOG; KOG1080; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   InParanoid; Q1DR06; -.
DR   KO; K11422; -.
DR   OrthoDB; 1017537at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR024657; COMPASS_Set1_N-SET.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR017111; Set1.
DR   InterPro; IPR024636; SET_assoc.
DR   InterPro; IPR001214; SET_dom.
DR   PANTHER; PTHR22884:SF462; PTHR22884:SF462; 1.
DR   Pfam; PF11764; N-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF11767; SET_assoc; 1.
DR   PIRSF; PIRSF037104; Histone_H3-K4_mtfrase_Set1_fun; 1.
DR   SMART; SM01291; N-SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51572; SAM_MT43_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1   1271       Histone-lysine N-methyltransferase, H3
FT                                lysine-4 specific.
FT                                /FTId=PRO_0000269770.
FT   DOMAIN     1129   1246       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN     1255   1271       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
SQ   SEQUENCE   1271 AA;  141606 MW;  DB6F21921726D001 CRC64;
     MSRAPAGFAD FFPTAPSVLQ KKRSKAAQDR HAANTPKAAD PLPNLGLSST PDIKGGVGTS
     ADNPVRAVGE RSAETTLALG DTNGATSSSS LSTGSSGFFS ASAPPGVAKP NGISSCALTP
     LTNTDSSPPC KIESPLGSKS GSTDAAPQLA PTCEAHGGPE PVTITPLHTP PTPRVQARPA
     NSEVKGHKIT YDPDLDRKFP SKARRRKPQY ETFGVDDEKD PPPCDPRMAI ANYTRGAACK
     QKTKYRPTPY ILRPWAYDPT TSVGPGPPTQ IVVTGFDPLT PIAAISALFS SFGDIGEINN
     RTDPMTGRFL GVCSIKYKDS RAFRGGISLS ASQAVRRAYL ECKKEQRIGT RRIRVELDRN
     GVVSGRMVAK LITAQKAEFP SLEESRKESV GDNDNRLPIG DGAKKDNEQS KDNLPPSTAP
     KGPSGRSSLH PSLLAPDGPR AVLKSPVPSR IEETPILQQI KRDPYIFIAH CYVPVLSTTV
     PHLERRLKLY DWKAVRCDKT GYYIIFENSR RGELEAERCY RMCHMTALFT YVMNMECQPY
     GNPNYERSPS PERIKAEKRE KAKRERLHRE MELDIEEEKR LRVENLDPAR EALSVLIIEL
     RDKLLDDVKS RVAAPALYDF LEPDRHNAKR QQLGIPAPEG TGRPSFRIDA STDGTVVHSQ
     PDAYSRHHRP GGVSSLNVLA LPRIRKVKGF EQGNAVYIDE RRRAKPRKRE FRPLYHRLQQ
     LHEIEDSDDD QQVSFARDTE EVESRPLSRL SSESAESDNE DDLMRKSPSL LDAKPLDVPL
     PESESLAGGI EQSGLPDREK SIIEELERGI NTLPTSSKKR KRLIEELATR KKRKEVDNLF
     ELDAKPLESL VEETAQEALP ADSTDALRTV TPVLKDKKRK VKGQSGKQIF EERQAPKRKE
     IDSTQPLLFE ESVELLPEGE IEISEPAIEE LKPEVEWGVS TDEPRPTAED DDTIVLDLDG
     WQSLIKDDED INFLKKALSE HLAADIGNLA AWTWKHKEIK AINRGGDRGP VHSETRIDGY
     YVPNPSGSAR TEGRKRIRES EKSKYLPHRI KVQKAREERL AKAKNDPHAA AAEAARLLAA
     KSLSKSTSRS TRVNNRRLIA DINAQKQALP MQNGDSDVLR FNQLKKRKKP VRFARSAIHN
     WGLYAEENIS ANDMIIEYVG EKVRQQVADM RERRYLKSGI GSSYLFRIDE NTVIDATKRG
     GIARFINHSC TPNCTAKIIK VDGSKRIVIY ALRDIDRDEE LTYDYKFERE WDSDDRIPCL
     CGSAGCKGFL N
//
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