ID ERB1_COCIM Reviewed; 843 AA.
AC Q1DRB6; A0A0D6K9P0; J3K3I5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=CIMG_07147;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; GG704912; EAS31668.1; -; Genomic_DNA.
DR RefSeq; XP_001243251.1; XM_001243250.2.
DR AlphaFoldDB; Q1DRB6; -.
DR SMR; Q1DRB6; -.
DR STRING; 246410.Q1DRB6; -.
DR GeneID; 4561045; -.
DR KEGG; cim:CIMG_07147; -.
DR VEuPathDB; FungiDB:CIMG_07147; -.
DR InParanoid; Q1DRB6; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 5472008at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..843
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370426"
FT REPEAT 487..526
FT /note="WD 1"
FT REPEAT 530..570
FT /note="WD 2"
FT REPEAT 668..706
FT /note="WD 3"
FT REPEAT 709..754
FT /note="WD 4"
FT REPEAT 758..797
FT /note="WD 5"
FT REPEAT 813..843
FT /note="WD 6"
FT REGION 36..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..138
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..391
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 94021 MW; 4AF026AD0F8631FD CRC64;
MTASSGGYQG WERRNNNIPE TVGILFLQVR AVSSGKKAAQ CRETAPTAGL SESSRPRLFA
MDYSKGSKKR KAITKDVDED PSVVSGDEYD LEALDRNDSD SSADASDSEI ELIGDFSSDD
GEDDDGEDDD ELDSDEVPSD TEPFARVKSG NIATGLDGSL DGESNDLSDD NEPNYRIEKD
ANGNDRYIYP EINPDDNSEY SEVDEEANTI GDIPLSFYDQ YPHIGYNING KKILRPAKGQ
ALDALLDSIE IPKGWTGLTD PSTGKPLQLS QEELELLRKV QMNEITQDGY DPYQPTIEYF
TSKQEIMPLS AAPEPKRRFI PSKHEAKRVM KIVKAIREGR ILPYKPPEEE DATQEGIQTY
DLWADESPRP DHPMNIPAPK LPPPGYEESY HPPPEYLPDK KEKEEWENQD EEDREREYLP
TDYSTLRKVP GYERFVKEKF ERCLDLYLAP RVRRSKLNID PESLLPKLPS PEELKPFPTT
CATLFRGHRG RVRSLAIDPT GVWLASGGDD GTVRVWELLT GRQLWSVKLS DEDAVNVVRW
RPGKEAVVLA ASVGDSIYLA VPDVVNLELE AASLEVIDAG WGYATSTGTS TTKKTSPVQW
TRPASSLADS GVYAVIPLGY IAKSISWHRR GDYFVTVCPG TSTPASVAIA IHTLSKHLTQ
YPFRRRLKGG GSPQVAHFHP SKPILFVANQ RSIRAYDLSR QTLVKILRPG ARWISSFDIH
PTSSSTSGGD NLIVGSYDRR LLWHDVDLSD RPYKTLRYHQ KAIRAVKYHP HYPLFADTSD
DGSLQIFHGS VTGDLLSNAN IVPLKVLKGH KVTGDLGVLD LDWHPREAWC VSAGADGTCR
LWM
//
