ID   Q1G8K4_LACDA            Unreviewed;       759 AA.
AC   Q1G8K4;
DT   27-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   27-JUN-2006, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=Putative helicase {ECO:0000313|EMBL:CAI98657.1};
GN   OrderedLocusNames=Ldb1919 {ECO:0000313|EMBL:CAI98657.1};
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081
OS   / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM
OS   00102 / Lb 14).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333 {ECO:0000313|EMBL:CAI98657.1, ECO:0000313|Proteomes:UP000001259};
RN   [1] {ECO:0000313|EMBL:CAI98657.1, ECO:0000313|Proteomes:UP000001259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 /
RC   NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14
RC   {ECO:0000313|Proteomes:UP000001259};
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P.,
RA   Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R.,
RA   Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P.,
RA   Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals extensive
RT   and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR954253; CAI98657.1; -; Genomic_DNA.
DR   RefSeq; WP_011544228.1; NZ_JQAV01000023.1.
DR   AlphaFoldDB; Q1G8K4; -.
DR   STRING; 390333.Ldb1919; -.
DR   KEGG; ldb:Ldb1919; -.
DR   PATRIC; fig|390333.13.peg.1128; -.
DR   eggNOG; COG3973; Bacteria.
DR   HOGENOM; CLU_010312_4_1_9; -.
DR   BioCyc; LDEL390333:LDB_RS08340-MONOMER; -.
DR   Proteomes; UP000001259; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR048228; HelD_bacillota.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   NCBIfam; NF041464; HelD_BACSU; 1.
DR   PANTHER; PTHR11070:SF17; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001259}.
FT   DOMAIN          209..601
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         230..237
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   759 AA;  87863 MW;  0A8D02F843838306 CRC64;
     MVENSDRKAE QAHLDQVLQK IDQKGDQLKQ AIAKDKSEAR NISAHFYDDI RLDFDDYSTS
     MDTALSIQQQ QQMLKERDNA WQVNARELAT LKRLHVHPYF ARVDFEEAGE EPESIYIGLA
     SFMDENNELL IYDWRAPISS IYYDGKIGKV TYYSPEGPVE VDMSKKRQFM IEDGTIINMF
     DTDETIGDQM LMEVLSEKSS IQMKSIVKTI QKEQNKIIRD TTSDLLFVQG AAGSGKTSAI
     LQRIAFLLYR YRGNLKSGNV IMFSPNQLFN DYIENVLPEM GEQNMVQMTY WQFIARRLPK
     MKVQNLFDQF EDRQADTAIG RFKDSLAFYK LATRYGQHLN QSGMIFRNIY FRTKKKPFFS
     KEEIKELYYS FNENYKLGNR IDATREELIR RLNKRVANEA RKVWVSREIE GLSHEQMLDM
     YDRPDQEFSS EKAERAFLGK KIVIKHLSKL ARRINHNGFL NLRGQYLAFL RAVPKMTDLA
     KYGISEEEWL THVEEVKAKF KEQEIDLRDA SAYLYLYDQI IARQTNLEMR YCFIDEIQDY
     SAFQLAYLRY NFPRAKFTML GDLNQAIFTK DESSSLLKQI SGLFDPEKTK LVQLTKSYRS
     TKQLTDYTKQ ILRHGEKIES FNRQGPLPQV WGRSDEAGAL AALKAALAEN DAQKLTTAII
     TKDLEAAKKL ADQLEGVHLI SSANQRLVEG NLVLPSYLAK GLEFDAVIMW DASKAAYHEE
     DETQLVYTIA SRAMYKLDLV YAGEKSPLLP TNEATFAKK
//