ID Q1H1Y8_METFK Unreviewed; 406 AA.
AC Q1H1Y8;
DT 27-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 27-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cobalamin synthesis protein, P47K {ECO:0000313|EMBL:ABE49499.1};
GN OrderedLocusNames=Mfla_1231 {ECO:0000313|EMBL:ABE49499.1};
OS Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylobacillus.
OX NCBI_TaxID=265072 {ECO:0000313|EMBL:ABE49499.1, ECO:0000313|Proteomes:UP000002440};
RN [1] {ECO:0000313|EMBL:ABE49499.1, ECO:0000313|Proteomes:UP000002440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT / ATCC 51484 / DSM 6875 {ECO:0000313|Proteomes:UP000002440};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT "Complete sequence of Methylobacillus flagellatus KT.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP000284; ABE49499.1; -; Genomic_DNA.
DR RefSeq; WP_011479453.1; NC_007947.1.
DR AlphaFoldDB; Q1H1Y8; -.
DR STRING; 265072.Mfla_1231; -.
DR KEGG; mfa:Mfla_1231; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_2_0_4; -.
DR OrthoDB; 9808822at2; -.
DR Proteomes; UP000002440; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047920; ZigA-like.
DR NCBIfam; NF038288; chaper_GTP_ZigA; 1.
DR PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002440}.
FT DOMAIN 259..374
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 406 AA; 45957 MW; 545263C99DC0C912 CRC64;
MKITRKLPVT VLSGFLGAGK TTLLNHILNN REDKRVAVIV NDMSEVNIDA QLIREGGAGL
SRSEEKLVEM SNGCICCTLR EDLLVEIKRL AEAGRFDYLL IESTGISEPL PVAETFTFRD
ENGASLSDIA RLDTMVTVVD AFNFLRDYAS RDMLAERGSS MGEGDERTVV DLLVEQVEFC
DVIVLNKTDL VNQEALQQLH GILKSFNPRA RIVESEFGRV PLARVLDTGL FDFAAAQSAP
GWLRELRGEH TPETEQYGIT SFVYRARRPF HPERLWRWFS REWPNVIRSK GYFWMASRPA
HCGSWSQAGS ITRHGPAGYW WAATPKAYWP EDMESLSAIR ERFSGEFGDR QQEIVLIGSS
MDKVALRQAF DHCLLTDAEL RLGMQAWKNF NDPFPAWDRQ PEESSA
//
