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Database: UniProt
Entry: Q1H389_METFK
LinkDB: Q1H389_METFK
Original site: Q1H389_METFK 
ID   Q1H389_METFK            Unreviewed;       158 AA.
AC   Q1H389;
DT   27-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   27-JUN-2006, sequence version 1.
DT   24-JAN-2024, entry version 112.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|ARBA:ARBA00013729, ECO:0000256|HAMAP-Rule:MF_00105};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   OrderedLocusNames=Mfla_0780 {ECO:0000313|EMBL:ABE49048.1};
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072 {ECO:0000313|EMBL:ABE49048.1, ECO:0000313|Proteomes:UP000002440};
RN   [1] {ECO:0000313|EMBL:ABE49048.1, ECO:0000313|Proteomes:UP000002440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875 {ECO:0000313|Proteomes:UP000002440};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC       {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family.
CC       {ECO:0000256|ARBA:ARBA00008213, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
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DR   EMBL; CP000284; ABE49048.1; -; Genomic_DNA.
DR   RefSeq; WP_011479145.1; NC_007947.1.
DR   AlphaFoldDB; Q1H389; -.
DR   STRING; 265072.Mfla_0780; -.
DR   KEGG; mfa:Mfla_0780; -.
DR   eggNOG; COG0782; Bacteria.
DR   HOGENOM; CLU_101379_2_0_4; -.
DR   OMA; TWLTQEA; -.
DR   OrthoDB; 9808774at2; -.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR   Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   NCBIfam; TIGR01462; greA; 1.
DR   PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF54534; FKBP-like; 1.
DR   SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:ABE49048.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ABE49048.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002440};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00105};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00105}.
FT   DOMAIN          4..74
FT                   /note="Transcription elongation factor GreA/GreB N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03449"
FT   DOMAIN          83..157
FT                   /note="Transcription elongation factor GreA/GreB C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01272"
SQ   SEQUENCE   158 AA;  16872 MW;  4EAFB6D18C86A4D0 CRC64;
     MNQIPITVKG AELLKAELQR LRSVDRPAVI QAIAEARAQG DLSENAEYDA AKERQSFIEG
     RIAEIEAKLS NAMIIDPATL NAEGRCVFGA TVEVEDLDSG EVSTYQIVGD DEADIKSGKI
     SIGSPIARAL IGKVEGDVAE VVAPGGLRSY EILSVKYI
//
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