ID Q1IKU2_KORVE Unreviewed; 820 AA.
AC Q1IKU2;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=2-oxoglutarate dehydrogenase E1 component {ECO:0000313|EMBL:ABF42508.1};
DE EC=1.2.4.2 {ECO:0000313|EMBL:ABF42508.1};
GN OrderedLocusNames=Acid345_3507 {ECO:0000313|EMBL:ABF42508.1};
OS Koribacter versatilis (strain Ellin345).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Koribacter.
OX NCBI_TaxID=204669 {ECO:0000313|EMBL:ABF42508.1, ECO:0000313|Proteomes:UP000002432};
RN [1] {ECO:0000313|EMBL:ABF42508.1, ECO:0000313|Proteomes:UP000002432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ellin345 {ECO:0000313|EMBL:ABF42508.1,
RC ECO:0000313|Proteomes:UP000002432};
RX PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000360; ABF42508.1; -; Genomic_DNA.
DR RefSeq; WP_011524307.1; NC_008009.1.
DR AlphaFoldDB; Q1IKU2; -.
DR STRING; 204669.Acid345_3507; -.
DR EnsemblBacteria; ABF42508; ABF42508; Acid345_3507.
DR KEGG; aba:Acid345_3507; -.
DR eggNOG; COG0567; Bacteria.
DR HOGENOM; CLU_004709_1_0_0; -.
DR OrthoDB; 9759785at2; -.
DR Proteomes; UP000002432; Chromosome.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 2.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABF42508.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002432};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 481..674
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 820 AA; 91508 MW; 640436A71D7C26FA CRC64;
MSTATINVAN EKQERILDAF RRWGHLQANI DPIGYFKPVA HPDLEFPEDE SEFARKIYCG
TIGVEFMHIA DPERRRWIAE KFEGEPGPVD HRRVLDALVR ADMFEQTLQS RYIGTKRYSL
EGNTSLIPLL HEILNAAAEH GAEQAVMAMS HRGRLNVIVN VVNRPAAEIF AGFEDVDPRS
VLGGGDVKYH IGSTGDYHAA NGQTVHIHLA SNPSHLEAVN PVAAGRVKAK QQRIGEGGIP
KVVPLIMHGD TAFAGQGIVA ETLNLEHLPG FDIGGTVHVI ANNLIGFTAN PREAYSSRYS
SDIAKRLEMP IIHVNAEDPD AVVRVGRIAM EYRDRFQSDV LVDLIGYRRH GHSEVDDPTI
TQPIVYRKIK DMPLISESYA AKIGADTKPM AEAVQAEWDV AQKEGKAMQK KPSMRDLPSY
WDPFKGGPWN ASLEVPTGLS TEELLKITEG ITSYPSDFNI HPKVAKLLEQ RREMGEGKKP
LDYGMAEALA FGSLVKNGVP VRLTGQDSKR GTFNQRHAVL IDIEDEHEYV PLANLAPNQA
WIEIYSSELS EAAVMGFEYG FARDFPEALV MWEAQFGDFA NGAQIIIDQF LVAGEDKWDL
LSGVVLLLPH GHEGQGPEHS SARIERYLQL CARDNMQVCQ PSNAAQYFHL LRRQALRKWR
KPLVCFTPKS MLRHPEAVSP LSDLTKPHFE TVVPDHEVQN AERLLLCTGK IGHELRMERR
RRRDTSTAIL SLDQIYPFPE NELEAALAQH PNARDFVWVQ EEPANMGALS FVEPRLHRII
GPGVRTIKRA ASATPATGSH KAHELEQKTL LNMAFTSIKN
//
