ID Q1IWN2_DEIGD Unreviewed; 349 AA.
AC Q1IWN2;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN OrderedLocusNames=Dgeo_2058 {ECO:0000313|EMBL:ABF46352.1};
OS Deinococcus geothermalis (strain DSM 11300 / AG-3a).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=319795 {ECO:0000313|EMBL:ABF46352.1, ECO:0000313|Proteomes:UP000002431};
RN [1] {ECO:0000313|Proteomes:UP000002431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11300 / AG-3a {ECO:0000313|Proteomes:UP000002431};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J.,
RA Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.;
RT "Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; CP000359; ABF46352.1; -; Genomic_DNA.
DR RefSeq; WP_011531178.1; NC_008025.1.
DR AlphaFoldDB; Q1IWN2; -.
DR STRING; 319795.Dgeo_2058; -.
DR KEGG; dge:Dgeo_2058; -.
DR eggNOG; COG3569; Bacteria.
DR HOGENOM; CLU_046978_1_1_0; -.
DR Proteomes; UP000002431; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00659; Topo_IB_C; 1.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000002431};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 22..70
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 89..284
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 349 AA; 39355 MW; 9DB2220C04F1F1A8 CRC64;
MAGRTDLLHE EYLRREGNKP GEFRYFWPDG EEYTDPEGLD RIAALAVPPA YTEVYVSPDP
DAELQAFGRD AAGRLQYRYH PDFVQAGALK KWQRLARFAG VLPTLRAVTA ADLRLSGLPR
RKVLAVMSRL LHVAHFRVGS DAYARAHRTY GLSTLRQRHV RVSGQDITFR FKGKHAILQE
KTVRNRTLAT NIERLLELPG PWLFQSVDEG ERTRVRAPDL NASLREVIGP FTAKDFRTWG
GTLLAAEFLA EAGPPETERQ ARKTIVECVK FVAADLGNTP AVTRGSYICP VIFDRYQAGK
VLDDYEPRAG RPEPELEGLT RSEAALKRML ESEQALRTRQ SRKKAKEAA
//
