ID Q1IY44_DEIGD Unreviewed; 1318 AA.
AC Q1IY44;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Dgeo_1545 {ECO:0000313|EMBL:ABF45840.1};
OS Deinococcus geothermalis (strain DSM 11300 / AG-3a).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=319795 {ECO:0000313|EMBL:ABF45840.1, ECO:0000313|Proteomes:UP000002431};
RN [1] {ECO:0000313|Proteomes:UP000002431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11300 / AG-3a {ECO:0000313|Proteomes:UP000002431};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J.,
RA Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.;
RT "Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000359; ABF45840.1; -; Genomic_DNA.
DR RefSeq; WP_011530674.1; NC_008025.1.
DR STRING; 319795.Dgeo_1545; -.
DR REBASE; 12689; DgeDORF1545P.
DR KEGG; dge:Dgeo_1545; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_002881_0_0_0; -.
DR Proteomes; UP000002431; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002431};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 469..543
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT REGION 1299..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 147484 MW; 2C5E0B8D91D73358 CRC64;
MNHAALRNIK VEGLGLSADF LLTLTDRTKS RALLDPESYG LAPKEPIEEG VSRSWDRLRK
AYARWTEARS ERPGTDPVRY WITPLLQELG HTDLQPNPAL TIGEKTYPIR FLGTVPVHVT
AGEDLDRITL HGSLRASPHG LVQEFLNRSG EHTWGLVLNG ERLRLLRDNA QVTRPAFVEF
DLEEMFDQGD SAGFRVLWLL THRSRFEGGE GAIIEGWNKQ ASAQGTRAND ALRDGVERAI
ATLGSGFLRR NRDLCAQLAT GERQAQDLYR LSLKLVYQLI FLFVVEDRDL LHPADTDPTA
KARYAHYSTR RLRQIAEASE GSATHGDAWE GLKVLLRGMY GGLPFLGLPA FGGHLFEQYP
LLACGLANSD LYAAIRALSL IEDGGTLKSV NFTDLDAEEL GSIYESLLEL HPEINTATGT
FTLSSAAGNE RKTTGSYYTP TGLIELLLES SLDPVIEDAL TKPDPVAALK ALNVVDPACG
SGHFLLAAAR RIGLALARAE HDVTQPSPEQ LRAATREVIA HCIYGVDLNP MAIELAKVAL
WLESAVPGKP LAFLDHRLRS GNSLLGTTPD LMRREDEIPE KLVRRVLKPA VKAVTLHLPD
EAFAELEGDD KTTVRALKNR NKQEREDLIE RAHGSQGLFD LQRDLSGLQR MVEALDRIEP
DSLEHVQAQE STWSAIQEHA EHRRLKTLAD AWCAAFVTPK TPGAPAITTR TLQDLDRNPD
SLPNVTALVG ELAEQYRFFH WHVEFPDVYA QGGFDCVLGN PPWERIKLQE KEWFAARVPE
IAAAPNAAAR TRLIAGLKTE QPAIYADFVR DLRQAEGESH FIRASGRYPL TGRGDVNTYA
IFSELCRQSL NPQGRMGIIV PTGIATDDTT KFFFQSLMDK ASLASLYDFE NREGIFPGVH
RSFKFCLLTV SGEERPNAQA QFAFFALNAD EARDPGKVFT LSPAEIALLN PNTRTAPVFR
SSRDAAITKG IYQRVPVLLN EATGENPWGI SFMRMFDMSN DSGLFRTAEQ LDADGWELHG
NRYRKGDGQM LPLYEAKLMH QFDHRFATYT ESGDTRDMTS AEKARADALP LPRYWVPQTE
VEDRLIQKDK NGNVIWEWTR DWLMGWRDIA RNTDERTFIG AVYPRRAAGD TFLQMLPDCP
VAQIPGLLGT LNSFAHDFAV RQKVGGTHLK YNVTRQFPVL PPSAFTPQRL AFITPRVLEL
TYTAHDLAGF ARDLGYDGPP FVWNDERRFW LRAELDALYF HLYGIPRDDV DYIMETFPIV
RRKDEAQYGT YRTKNAILEI YDELARVGLE GYRTRLSPGP ADARAAHGAQ VEAQRSWG
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