ID Q1K628_NEUCR Unreviewed; 611 AA.
AC Q1K628;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 13-SEP-2023, entry version 60.
DE SubName: Full=Purine transporter {ECO:0000313|EMBL:EAA28707.3};
GN ORFNames=NCU04625 {ECO:0000313|EMBL:EAA28707.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA28707.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA28707.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002240; EAA28707.3; -; Genomic_DNA.
DR RefSeq; XP_957943.3; XM_952850.3.
DR AlphaFoldDB; Q1K628; -.
DR STRING; 367110.Q1K628; -.
DR EnsemblFungi; EAA28707; EAA28707; NCU04625.
DR GeneID; 3874090; -.
DR KEGG; ncr:NCU04625; -.
DR VEuPathDB; FungiDB:NCU04625; -.
DR HOGENOM; CLU_024508_3_2_1; -.
DR InParanoid; Q1K628; -.
DR OrthoDB; 35157at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015853; P:adenine transport; IBA:GO_Central.
DR GO; GO:0015854; P:guanine transport; IBA:GO_Central.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337:SF3; PURINE TRANSPORTER; 1.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 586..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 66328 MW; 01979AA022A014B7 CRC64;
MVGTTGVRLS DNPDEIPDTP RRSIFRRGFA YATEAINGGV DSVNRKVSST YVGRFFRLRG
SGHAEEIRDA NFCTEIRAGL ITFSAMLYVL AANPAVIASS GYECSCRGED KGRPNCGQDY
QACIEELRRD MVAVTAAVSA MSCILFGLMT NMPVAVAPGM GLNSYFAYQV IGIRGSGLLP
WRSALTAVFL EGWIFIILSL TGLRHWLVRI IPSTMKVAGV CGIGLFLALT GLANNTGLGL
ITSGDVVPIS LADCSNPDQQ GQCSGVSAIA DPKLWLGILG GGILPTVLMG FNNKYSIGIG
VLFVTLMSIP RSTSVTFFPY NSVGQNKWDY FSSMVGVRKT GFDMSQLRFD FGPHQGNFVV
ALLTMLYVDM IDCTATLQGL ARYTYRLQGP DPDFPGSTIA YCTNAFCISM GALLGSSPVT
VFVESGAGAQ SGGRTGIAAI VTGLCFLAAV FFAPFFSGIP PWATGPALIL IGFLMVRQIY
SINWNYAGDA IPSFVTIMFI PFSYSVAYGL IAGLFTYIIV NGLIWIISTL TGVEPHDYHL
KQYWTINPVG RKPWIYRAYK YIMAKLQTNR DQVTEEVAVQ EFEMMERRTS HPRSAVASAS
TMDDKHSRTA E
//
