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Database: UniProt
Entry: Q1K640_NEUCR
LinkDB: Q1K640_NEUCR
Original site: Q1K640_NEUCR 
ID   Q1K640_NEUCR            Unreviewed;      1020 AA.
AC   Q1K640;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 2.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Beta-galactosidase {ECO:0000313|EMBL:EAA28943.2};
GN   Name=gh35-2 {ECO:0000313|EMBL:EAA28943.2};
GN   ORFNames=NCU04623 {ECO:0000313|EMBL:EAA28943.2};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA28943.2, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA28943.2, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D., FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; CM002240; EAA28943.2; -; Genomic_DNA.
DR   RefSeq; XP_958179.2; XM_953086.2.
DR   CAZy; GH35; Glycoside Hydrolase Family 35.
DR   EnsemblFungi; EAA28943; EAA28943; NCU04623.
DR   GeneID; 3874326; -.
DR   KEGG; ncr:NCU04623; -.
DR   EuPathDB; FungiDB:NCU04623; -.
DR   InParanoid; Q1K640; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005618; C:cell wall; IBA:GO_Central.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001805};
KW   Glycosidase {ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28   1020       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004192782.
FT   DOMAIN      406    587       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   1020 AA;  112118 MW;  C73C46A55FFCC132 CRC64;
     MRFANKGFES FAYALLLLSS GRQYVLGASD TPSAWPIQGN DLQDQIQWDH YSIIINGERL
     FLFGGEMHPF RLPVPELWQD VLEKVKAMGM RMISIYTHWG FHAPTPDQTD FSTGAHNLTR
     FFEMAKEVGL YVLVRPGPYI NGELNAGGLA LWSTTGSYGE LRSNGSAFTE AWTPYQTGIA
     KLVKPFQLTD GGTVIMYQLE NEYGEQWKNV DAKIPNPKAV SYMEKLKENA IENGIVVPSV
     HNAPNANGRP WSRDYDTVGA GGDVDIYGLD SYPQCWSCVT EECGNNILPF AVSNYHDHFQ
     LVSPNQPSFM PEFQGGAMSP WLSPAGGCAE RTGPEFVNFY YRDNIAQRIT ILNLYMIYGG
     TNWGWLAAPF LGSSYDYGAA ISEDRNIGSK YYEIKNLGLF TRAADELAYT DRVGTGTNYT
     NNTNIFTTEL KNPKTGARFY VLRHATTSSD STETFAINVT TSLGSFYVPR IAPCPKLVGH
     EGKIFVADFH FGKHTLFYAT TEVLTYSVIN QKTTLVLWTP IGISGEFYLK GAKKGTLTSS
     SKGQTAVFDG QDDGVVVGFT QREGATVLEF DNDVRVVLVD RDTAYKTWVP ALTKDPKVPV
     DKTAIVVGPR LVRSASVQGN TISVKGDCND TTGIEVFTSS HVSTIKWNGK QLRTTQTNYG
     TLKASLQAPA RFSAPKFASW KSQDSLPETA VGYSDDGPAW VIANHTTTYS ATKGTVPYLF
     SDEYGFHTGI RLWRGHFSGE FGATGVYLTI QGGTAHSWSA FLNGKFLGSY TGNPTVAASN
     ATLSFANVPI FTNQTNVLLV MHDDTGHDQL SAALNPRGIL NATLLSSNSS TTPKFNLWKL
     AGTAGGFDPS RSTLDPLRTH YNEGGLSAER LGWHLPDFDD SNWSSPLTSP AQGFTGATIR
     FYRTSLPLNV PKGVDASFAF KFTPVDTSNL NYRAFLYVNG YQYGRYYPSI ASENVFPVPA
     GVLNLGGDNV IGLAVWAQTE KGAKVDVELV TRYAVESSFE SRFDGTYLQP GWTKERLDYA
//
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