ID Q1K7M3_NEUCR Unreviewed; 336 AA.
AC Q1K7M3;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Gamma-tocopherol methyltransferase {ECO:0000313|EMBL:EAA32049.3};
GN ORFNames=NCU04129 {ECO:0000313|EMBL:EAA32049.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32049.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA32049.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. gTMT family. {ECO:0000256|PROSITE-ProRule:PRU00914}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00914}.
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DR EMBL; CM002240; EAA32049.3; -; Genomic_DNA.
DR RefSeq; XP_961285.3; XM_956192.3.
DR AlphaFoldDB; Q1K7M3; -.
DR STRING; 367110.Q1K7M3; -.
DR PaxDb; 5141-EFNCRP00000003917; -.
DR EnsemblFungi; EAA32049; EAA32049; NCU04129.
DR GeneID; 3877449; -.
DR KEGG; ncr:NCU04129; -.
DR VEuPathDB; FungiDB:NCU04129; -.
DR HOGENOM; CLU_039068_1_0_1; -.
DR InParanoid; Q1K7M3; -.
DR OrthoDB; 2283604at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025774; MTs_g-TMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR44068:SF11; GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF02353; CMAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51581; SAM_GTMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00914,
KW ECO:0000313|EMBL:EAA32049.3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00914};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00914}.
FT REGION 99..108
FT /note="SAM motif I"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00914"
FT REGION 214..223
FT /note="SAM motif III"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00914"
SQ SEQUENCE 336 AA; 37272 MW; 68C24158B0F8FC6A CRC64;
MAAVTSQTPQ TGQDEVTDLS KQYDTPMGLA HSTMQALKDR IKLHYDLASD YYLNLWGEHI
HHGYWATDEA KAKDTKEVAQ VNLIRLLLEI SKVSEGARVL DTGCGIGGTS RFLASELGCT
VTGITISTKQ VEMATRLTKA EAAKQIQGDD KTVTPDADGF IALGKGKVRF LELDAEKMGE
YFASDAGTLD AVWISEALSH FPNKALFFQN AFKVLKQGGK LVLADWFKGE ELNQTQFDND
IKPIEDGMLL PPLCTQPDYV KFATDAGLKV FHEPKDISKD VSKTWDISWS LVQNPSLWAF
AFSQGRDGIA FLQAFRAMRR GYSNGSFRYA VMSFQK
//
