ID Q1K7M9_NEUCR Unreviewed; 842 AA.
AC Q1K7M9;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=AP-1 complex subunit gamma {ECO:0000256|PIRNR:PIRNR037094};
GN ORFNames=NCU04121 {ECO:0000313|EMBL:EAA32041.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32041.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA32041.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037094}.
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DR EMBL; CM002240; EAA32041.3; -; Genomic_DNA.
DR RefSeq; XP_961277.3; XM_956184.3.
DR AlphaFoldDB; Q1K7M9; -.
DR STRING; 367110.Q1K7M9; -.
DR PaxDb; 5141-EFNCRP00000003905; -.
DR EnsemblFungi; EAA32041; EAA32041; NCU04121.
DR GeneID; 3877441; -.
DR KEGG; ncr:NCU04121; -.
DR VEuPathDB; FungiDB:NCU04121; -.
DR HOGENOM; CLU_003824_0_0_1; -.
DR InParanoid; Q1K7M9; -.
DR OrthoDB; 25313at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0030121; C:AP-1 adaptor complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0035615; F:clathrin adaptor activity; IBA:GO_Central.
DR GO; GO:0016482; P:cytosolic transport; IEA:UniProt.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.40.1230; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017107; AP1_complex_gsu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008153; GAE_dom.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF5; AP-1 COMPLEX SUBUNIT GAMMA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR PIRSF; PIRSF037094; AP1_complex_gamma; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR PROSITE; PS50180; GAE; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037094};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037094};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037094}.
FT DOMAIN 730..842
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
SQ SEQUENCE 842 AA; 92000 MW; 112FD712C384891D CRC64;
MSSLKQFIRN VRAAKTIADE RAVIQKESAA IRASFREESH DHSVRRNNVA KLLYLFTLGE
RTHFGQIECL KLLASPRFAD KRLGHLATSL LLDENQEVLT LVTNSLQNDL NHSNQYVVGL
ALCTLGNIAS VEMSRDLFPQ IETLISTTNP YIRRKAALCA MRICKKVPDL QEHFVEKAAQ
LLSDRNHGVL LCGLTLVTSL CEADEAEGGE EGIIEKFRQF VPVLVRTLKG LASSGYAPEH
DVTGITDPFL QVKILRLLRV LARGDAQTTE QINDILAQVA TNTDATKNVG NSILYEAVLT
ILDIEADAGL RVLGVNILGK FLANKDNNIR YVALNTLVKV VAIDTNAVQR HRNTILECLR
DPDISIRRRA LDLSFTLINE SNVRVLIREL LAFLEVADNE FKPNMTSQIG IAADRYAPNK
RWHVDTMLRV LTLAGNYVKE PILSSFIRLI ATTPELQTYA VQKLYTNLKK DITQESLTQA
GAWCIGEYGD ALLRGGQYEE EELVQEVKEH ELIDLFTTIL NSNYATQVTT EYIITALIKL
TTRLQDATQI ERVRRLLQYH QTSLDVEVQQ RAVEYGNLFS FDQIRRGVLE KMPPPQIKES
SRVLGEAAKK TTKAAGKKTN KAAKPKEEDL LFDLMGDTNL PSPSVPNGGT NNADLLADIL
GGTTSPPTSA SPAPAQSNVA SIMDLFSQGP TSTPSPAPAP AAAPSAVLDL FNTTPAAASA
PAPQAAPKPA AAAGHACYDN NGLNVTIQIQ RNAEGMIQAT ARFRNSFPGG PLSAVGLQAA
VPKSQKLQLL NISSTDIAPG AEATQMMRVA GCTGALRLRL KIGYTHPTAG QVLDLVNWTE
PS
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