GenomeNet

Database: UniProt
Entry: Q1L8B0_DANRE
LinkDB: Q1L8B0_DANRE
Original site: Q1L8B0_DANRE 
ID   Q1L8B0_DANRE            Unreviewed;       567 AA.
AC   Q1L8B0;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   03-JUL-2019, entry version 93.
DE   SubName: Full=Sorting nexin 27a {ECO:0000313|Ensembl:ENSDARP00000114388};
GN   Name=snx27a {ECO:0000313|Ensembl:ENSDARP00000114388,
GN   ECO:0000313|ZFIN:ZDB-GENE-060503-371};
GN   Synonyms=si:dkeyp-39e9.2 {ECO:0000313|ZFIN:ZDB-GENE-060503-371};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000114388, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000114388, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114388,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000114388}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114388};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
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DR   EMBL; CR931759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001038565.1; NM_001045100.1.
DR   STRING; 7955.ENSDARP00000044525; -.
DR   PaxDb; Q1L8B0; -.
DR   Ensembl; ENSDART00000144925; ENSDARP00000114388; ENSDARG00000033804.
DR   GeneID; 566205; -.
DR   KEGG; dre:566205; -.
DR   CTD; 566205; -.
DR   ZFIN; ZDB-GENE-060503-371; snx27a.
DR   eggNOG; ENOG410IMRD; Eukaryota.
DR   eggNOG; ENOG410XPAD; LUCA.
DR   GeneTree; ENSGT00950000183212; -.
DR   HOGENOM; HOG000016641; -.
DR   KO; K17936; -.
DR   OMA; MASYFAL; -.
DR   OrthoDB; 395943at2759; -.
DR   PhylomeDB; Q1L8B0; -.
DR   Proteomes; UP000000437; Chromosome 19.
DR   Bgee; ENSDARG00000033804; Expressed in 17 organ(s), highest expression level in intestine.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:1990126; P:retrograde transport, endosome to plasma membrane; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13338; FERM-like_C_SNX27; 1.
DR   CDD; cd06886; PX_SNX27; 1.
DR   CDD; cd01777; SNX27_RA; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR001683; Phox.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR037831; SNX17/27/31.
DR   InterPro; IPR037827; SNX27_FERM-like_dom.
DR   InterPro; IPR037833; SNX27_PX.
DR   InterPro; IPR037835; SNX27_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12431; PTHR12431; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS50200; RA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q1L8B0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN       46    139       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      164    272       PX. {ECO:0000259|PROSITE:PS50195}.
FT   DOMAIN      276    365       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION        1     39       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q1L8B0}.
SQ   SEQUENCE   567 AA;  64351 MW;  54D4256C7DAEA95E CRC64;
     MAEIEGDETV RPAPPSVLPA APRVNGSGML GSGSQTPTMV ASGPRVVRII KSESGYGFNV
     RGQVSEGGQL RSINGELYAP LQHVSAVLPG GAADRAGIVK GDRILEVNGV SVEGATHKQV
     VDLIRAGERE LVLTVLSIPA QEADGLDTSE EGAVQPNYDY SDKQAVPISV PTYKHVEQHS
     EKFVVYNVYM SGRQLCSKRY REFAILHQNL KREFSNYTFP KLPGKWPFSL SEQQLDARRR
     GLEEYMERVC SVRIIGESDI MQEFLSESNE NHNGITDVEL RIALPDKTTA SVRVQKNSTT
     DQVYQALVVK VGMDSMMASY FALFEVINHS FVRKLAPNEF PHKLYVQNYT SAVPGTCLTM
     RKWLFSTQEE DLLRDNPLAL HYCFHQAQDD VKKGFIKAED KAYQLQKLAE QRKMTTYLSL
     LRSCEGYNEV TFPHCPCDSR RKGHVITAVS MKHFKLHACT EDGTLENQVI MFEWSEMQRW
     DTDEEGMAFC FEYVRGEKKP RWVKIFTPYF NYMHECFERI FCELKWRKEV EEEASDKGNK
     NCSNNEYLSP LEQQKGWRHL GGEIATS
//
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