ID Q1L907_DANRE Unreviewed; 226 AA.
AC Q1L907; A2V6B0;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
GN Name=gstr {ECO:0000313|Ensembl:ENSDARP00000062517,
GN ECO:0000313|ZFIN:ZDB-GENE-090507-1};
GN Synonyms=gstR1 {ECO:0000313|EMBL:BAF47195.1}, gstr1
GN {ECO:0000313|RefSeq:NP_001038525.1}, tfa
GN {ECO:0000313|ZFIN:ZDB-GENE-090507-1}, zgc:162356
GN {ECO:0000313|RefSeq:NP_001038525.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:BAF47195.1};
RN [1] {ECO:0000313|EMBL:BAF47195.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole body {ECO:0000313|EMBL:BAF47195.1};
RA Konishi T., Tamaru Y., Takagi M.;
RT "Rho-class glutathione S-transferases from zebrafish.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAI39573.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAI39573.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI39573.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=20419347;
RA da Rosa C.E., Figueiredo M.A., Lanes C.F., Almeida D.V., Marins L.F.;
RT "Genotype-dependent gene expression profile of the antioxidant defense
RT system (ADS) in the liver of a GH-transgenic zebrafish model.";
RL Transgenic Res. 20:85-89(2011).
RN [4] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=23427857;
RA Hagenaars A., Vergauwen L., Benoot D., Laukens K., Knapen D.;
RT "Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests
RT mitochondrial dysfunction to play a key role in PFOA toxicity.";
RL Chemosphere 91:844-856(2013).
RN [5] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=23770340;
RA Timme-Laragy A.R., Goldstone J.V., Imhoff B.R., Stegeman J.J., Hahn M.E.,
RA Hansen J.M.;
RT "Glutathione redox dynamics and expression of glutathione-related genes in
RT the developing embryo.";
RL Free Radic. Biol. Med. 65:89-101(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000062517, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062517};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000062517}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062517};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=25005048;
RA Hou J., Li L., Xue T., Long M., Su Y., Wu N.;
RT "Damage and recovery of the ovary in female zebrafish i.p.-injected with
RT MC-LR.";
RL Aquat. Toxicol. 155:110-118(2014).
RN [9] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=25119852;
RA Rola R.C., Marins L.F., Nery L.E., da Rosa C.E., Sandrini J.Z.;
RT "Responses to ROS inducer agents in zebrafish cell line: differences
RT between copper and UV-B radiation.";
RL Fish Physiol. Biochem. 40:1817-1825(2014).
RN [10] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=28865787;
RA Chen Q.L., Sun Y.L., Liu Z.H., Li Y.W.;
RT "Sex-dependent effects of subacute mercuric chloride exposure on histology,
RT antioxidant status and immune-related gene expression in the liver of adult
RT zebrafish (Danio rerio).";
RL Chemosphere 188:1-9(2017).
RN [11] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=29289830;
RA Lin W., Hou J., Guo H., Li L., Wang L., Zhang D., Li D., Tang R.;
RT "The synergistic effects of waterborne microcystin-LR and nitrite on
RT hepatic pathological damage, lipid peroxidation and antioxidant responses
RT of male zebrafish.";
RL Environ. Pollut. 235:197-206(2018).
RN [12] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=29361160;
RA Tierbach A., Groh K.J., Schonenberger R., Schirmer K., Suter M.J.;
RT "Glutathione S-Transferase Protein Expression in Different Life Stages of
RT Zebrafish (Danio rerio).";
RL Toxicol. Sci. 162:702-712(2018).
RN [13] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=30682622;
RA Basica B., Mihaljevic I., Marakovic N., Kovacevic R., Smital T.;
RT "Molecular characterization of zebrafish Gstr1, the only member of teleost-
RT specific glutathione S- transferase class.";
RL Aquat. Toxicol. 208:196-207(2019).
RN [14] {ECO:0000313|RefSeq:NP_001038525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RX PubMed=30388543;
RA Ni H., Peng L., Gao X., Ji H., Ma J., Li Y., Jiang S.;
RT "Effects of maduramicin on adult zebrafish (Danio rerio): Acute toxicity,
RT tissue damage and oxidative stress.";
RL Ecotoxicol. Environ. Saf. 168:249-259(2019).
RN [15] {ECO:0000313|RefSeq:NP_001038525.1}
RP IDENTIFICATION.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001038525.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710};
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DR EMBL; CR391989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC139572; AAI39573.1; -; mRNA.
DR EMBL; AB214517; BAF47195.1; -; mRNA.
DR RefSeq; NP_001038525.1; NM_001045060.2.
DR STRING; 7955.ENSDARP00000062517; -.
DR PaxDb; 7955-ENSDARP00000062517; -.
DR Ensembl; ENSDART00000062518; ENSDARP00000062517; ENSDARG00000042620.
DR Ensembl; ENSDART00000062518.7; ENSDARP00000062517.6; ENSDARG00000042620.8.
DR GeneID; 564619; -.
DR KEGG; dre:564619; -.
DR AGR; ZFIN:ZDB-GENE-090507-1; -.
DR CTD; 564619; -.
DR ZFIN; ZDB-GENE-090507-1; gstr.
DR eggNOG; KOG4420; Eukaryota.
DR HOGENOM; CLU_011226_5_4_1; -.
DR OMA; SAERYPQ; -.
DR OrthoDB; 803504at2759; -.
DR TreeFam; TF334372; -.
DR Proteomes; UP000000437; Chromosome 19.
DR Bgee; ENSDARG00000042620; Expressed in liver and 26 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043295; F:glutathione binding; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IDA:ZFIN.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR CDD; cd00299; GST_C_family; 1.
DR CDD; cd00570; GST_N_family; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43900; GLUTATHIONE S-TRANSFERASE RHO; 1.
DR PANTHER; PTHR43900:SF96; GSTR1 PROTEIN; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q1L907};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|EMBL:BAF47195.1}.
FT DOMAIN 3..85
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 92..218
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 226 AA; 26409 MW; 6C68160FA5AE466E CRC64;
MAQNMLLYWG TGSPPCWRLM IALEEKQLQG YKHKLLSFDK KEHQSPEVKA LNPRAQLPTF
KHGEIVVNES FAACLYLESV FKSQGTRLIP DNPAEMALVY QRMFETENLQ QKMYEVAFYD
WLVPEGERLE SALKRNKEKL IEELKLWEGY LEKMGKGSYL AGKNFSMADV VCFPVIAYFP
RLQCPKERCP RLMEYYEMVK DRPSIKASWP PEWLEKPVGE DILKSL
//
