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Database: UniProt
Entry: Q1LFS7_CUPMC
LinkDB: Q1LFS7_CUPMC
Original site: Q1LFS7_CUPMC 
ID   Q1LFS7_CUPMC            Unreviewed;       377 AA.
AC   Q1LFS7;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=Rmet_4132 {ECO:0000313|EMBL:ABF10999.1};
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507
OS   / CH34) (Ralstonia metallidurans).
OG   Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429}.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF10999.1, ECO:0000313|Proteomes:UP000002429};
RN   [1] {ECO:0000313|Proteomes:UP000002429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC   {ECO:0000313|Proteomes:UP000002429};
RC   PLASMID=Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429};
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N.,
RA   Michaux A., Benotmane M.A., Leys N., Vallaeys T., Lapidus A.,
RA   Monchy S., Medigue C., Taghavi S., McCorkle S., Dunn J.,
RA   van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain
RT   CH34, a master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP000353; ABF10999.1; -; Genomic_DNA.
DR   RefSeq; WP_011518624.1; NC_007974.2.
DR   STRING; 266264.Rmet_4132; -.
DR   EnsemblBacteria; ABF10999; ABF10999; Rmet_4132.
DR   GeneID; 24154255; -.
DR   KEGG; rme:Rmet_4132; -.
DR   HOGENOM; HOG000281564; -.
DR   KO; K00627; -.
DR   OMA; RAMAQNM; -.
DR   OrthoDB; 1626282at2; -.
DR   BioCyc; CMET266264:GJ5G-4489-MONOMER; -.
DR   Proteomes; UP000002429; Plasmid megaplasmid CH34.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ABF10999.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002429};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Plasmid {ECO:0000313|EMBL:ABF10999.1};
KW   Pyruvate {ECO:0000313|EMBL:ABF10999.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002429};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ABF10999.1}.
FT   DOMAIN        1     76       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      117    154       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
SQ   SEQUENCE   377 AA;  39388 MW;  4247903E6AC8BCA5 CRC64;
     MRIFKLPDLG EGLQEAEIVN WHVKPGDTIA ADQPLLSVET AKAIVEIPSP FAGQVAKLFA
     QPGDIVHLGA PLVGFEGAGA SDDAGTVVGA VKVGTHVVNE GVTRVGAAGI PGGHGIKATP
     AVRALARKLS VDLSMVTPSG HDGVITATDV QRVATTLADV GAPDVLRGVR RAMAQNMARA
     QSEVAAATVM DDADLHAWQA TGASVTGQDI TIRLVRALVA GVRAEPALNA WYEGRTGRRH
     LLERIDVGIA ADLPEGLFVP VLRNVGKRDA ADLRAGLDRM RADVVARTIA PEEMRGNTIT
     LSNFGMIAGR YAAPIVVPPT VAILGAGRVR DEVVASGGVP AVHRVMPLSL TFDHRVVTGG
     EAARFLRAVI EDLERPE
//
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