ID Q1LIR3_CUPMC Unreviewed; 678 AA.
AC Q1LIR3;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=pehS {ECO:0000313|EMBL:ABF09963.1};
GN OrderedLocusNames=Rmet_3091 {ECO:0000313|EMBL:ABF09963.1};
OS Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS CH34) (Ralstonia metallidurans).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF09963.1, ECO:0000313|Proteomes:UP000002429};
RN [1] {ECO:0000313|Proteomes:UP000002429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC {ECO:0000313|Proteomes:UP000002429};
RX PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT master survivalist in harsh and anthropogenic environments.";
RL PLoS ONE 5:E10433-E10433(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000352; ABF09963.1; -; Genomic_DNA.
DR RefSeq; WP_011517591.1; NC_007973.1.
DR AlphaFoldDB; Q1LIR3; -.
DR STRING; 266264.Rmet_3091; -.
DR KEGG; rme:Rmet_3091; -.
DR eggNOG; COG0642; Bacteria.
DR HOGENOM; CLU_000445_114_39_4; -.
DR Proteomes; UP000002429; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF52; SENSOR PROTEIN KINASE PILS; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ABF09963.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002429};
KW Transferase {ECO:0000313|EMBL:ABF09963.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..266
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 429..663
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 678 AA; 75038 MW; 68C33283959E03EC CRC64;
MTAPASAWSH LNGWRVLVKL WRQSEPPEFH WRLQRYFCWT RLAVAVLLVG YAWLPLERAA
AGADVFNVAT NARLASAMPV VLPYLAIALV TLFGTLWRNH FHVRVRVQVL VDLVLLASIY
AALGHFGSQG EGLAMIFLLP VIEAGALTSL TFALFAASVS ALLVMGPPLL QTLITRQVDV
NLLGSGLFGL VFMIAALVMY MLANRQIAQE QLALAREQEL RLQQLVNRLM VNDMQDGVML
VRANGVVVAA NPAALVLLGV QQNERIREGQ VRVGERENVL FDLRRMPRLQ PLLEMLRDWI
RMKDDVPRIL QLLPLPSRPS SSARNSMHTR LRLRFVLPGL AGLRSTLAGA LTSPSGLDTT
SWNDMSPEGA ARLRLAIAQN EAMAWSPADE ALLRSEMRDT VLVHIESWER IAEQVQQEKL
AAMGRLVASV AHQIRNPLAA ISQANELLAD SGGGEGNIDA RLLRIISDNV RRLDQVISDV
LQLSRRPRTG HSAVDLAKAL PEVVDRWRLE MRSRAGARAE VNANAIRITV DLKGPVIFDM
SQLQQVLGNL LDNAWRYCSR LPGAIRLLAH TLDQHHAELI VWNDGAEVTR EQQRSLFEPF
FTSNPQGTGL GLFMARELCG ANDAQVRYGA IVLEDLLDRT GMLVGARDTL PGKAFVLTLR
NEVPDVANAQ PFQPSAKL
//
