ID Q1LSU3_BAUCH Unreviewed; 224 AA.
AC Q1LSU3;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759,
GN ECO:0000313|EMBL:ABF14144.1};
GN OrderedLocusNames=BCI_0541 {ECO:0000313|EMBL:ABF14144.1};
OS Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Baumannia.
OX NCBI_TaxID=374463 {ECO:0000313|EMBL:ABF14144.1, ECO:0000313|Proteomes:UP000002427};
RN [1] {ECO:0000313|EMBL:ABF14144.1, ECO:0000313|Proteomes:UP000002427}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hc {ECO:0000313|EMBL:ABF14144.1};
RX PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H.,
RA Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.;
RT "Metabolic complementarity and genomics of the dual bacterial symbiosis of
RT sharpshooters.";
RL PLoS Biol. 4:1079-1092(2006).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; CP000238; ABF14144.1; -; Genomic_DNA.
DR RefSeq; WP_011520704.1; NC_007984.1.
DR AlphaFoldDB; Q1LSU3; -.
DR STRING; 374463.BCI_0541; -.
DR KEGG; bci:BCI_0541; -.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OrthoDB; 5634909at2; -.
DR Proteomes; UP000002427; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00759};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759};
KW Reference proteome {ECO:0000313|Proteomes:UP000002427}.
FT DOMAIN 56..154
FT /note="DNA mismatch repair MutH/Type II restriction enzyme
FT Sau3AI"
FT /evidence="ECO:0000259|SMART:SM00927"
SQ SEQUENCE 224 AA; 24922 MW; E9381D36DE922FC3 CRC64;
MFLSLTPPAN EIELLYRAKK LAGLSLGELA VHANIVTPNN LKRDKGWIGL LLEKYLGASA
GNKPEQDFAT IGIELKTIPV DNNGRSLETT FVCTAPLTGK TGITWEVSYV RYKLARVLWI
PVEGQREIPV AQRHIGTPIL WSPSAQEALQ LQCDWEELMD LIVLGNVKHI TAKYGKVLQL
RPKAANSLVL TTAIGKLGEP IRTMPLGFYL KKNFTNQLLA RNFY
//
