ID Q1LWF2_DANRE Unreviewed; 400 AA.
AC Q1LWF2; A0A8M1N9Q7;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=ethanolamine kinase {ECO:0000256|ARBA:ARBA00038874};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
GN Name=chka {ECO:0000313|Ensembl:ENSDARP00000060014,
GN ECO:0000313|RefSeq:NP_001038330.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050208-149};
GN Synonyms=im:7143625 {ECO:0000313|RefSeq:NP_001038330.1},
GN si:dkey-12e7.3 {ECO:0000313|RefSeq:NP_001038330.1}, wu:fd46h01
GN {ECO:0000313|RefSeq:NP_001038330.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000060014};
RN [1] {ECO:0000313|RefSeq:NP_001038330.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2] {ECO:0000313|RefSeq:NP_001038330.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX PubMed=23919627;
RA Fu J., Han J., Zhou B., Gong Z., Santos E.M., Huo X., Zheng W., Liu H.,
RA Yu H., Liu C.;
RT "Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-
RT 2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of
RT developmental toxicity.";
RL Environ. Sci. Technol. 47:10574-10582(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000060014, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060014};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000060014}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060014};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001038330.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX PubMed=29339408;
RA Chen T., Song G., Yang H., Mao L., Cui Z., Huang K.;
RT "Development of the Swimbladder Surfactant System and Biogenesis of
RT Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish.";
RL Genetics 208:1131-1146(2018).
RN [6] {ECO:0000313|RefSeq:NP_001038330.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR EMBL; BX571884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038330.1; NM_001044865.1.
DR Ensembl; ENSDART00000060015; ENSDARP00000060014; ENSDARG00000041078.
DR Ensembl; ENSDART00000060015.8; ENSDARP00000060014.6; ENSDARG00000041078.8.
DR GeneID; 558499; -.
DR KEGG; dre:558499; -.
DR AGR; ZFIN:ZDB-GENE-050208-149; -.
DR CTD; 1119; -.
DR ZFIN; ZDB-GENE-050208-149; chka.
DR HOGENOM; CLU_012712_2_1_1; -.
DR OrthoDB; 144299at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 18.
DR Proteomes; UP000000437; Chromosome 18.
DR Bgee; ENSDARG00000041078; Expressed in head kidney and 22 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004103; F:choline kinase activity; IBA:GO_Central.
DR GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR GO; GO:0006657; P:CDP-choline pathway; IBA:GO_Central.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05156; ChoK_euk; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF103; CHOLINE KINASE ALPHA ISOFORM X1; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:NP_001038330.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|RefSeq:NP_001038330.1}.
SQ SEQUENCE 400 AA; 46577 MW; 93F7D9C69DF0FF2A CRC64;
MKTKFINGVS SSPSMSLGLL VNESVLEVQP DSVNDCKDII RPDEPDQQTK HKAYLWCREF
LHGAWKSIDE EDFQISIIRG GLSNKLFLCA LPEMQASLGD EPRNVLLRLY GEILQGADAM
VLESVMFAIL AERELGPKLY GIFPQGRLEQ FVPSRKLTTD ELSVPGINAE IAEKIARFHG
MRMPFNKEPK WLFGTMEKYM DQVLQLTFTR EPHLRNFSRI LSYNLPQEMD NLKCLLESTP
SPVVFCHNDL QEGNILLLNG RENTDRQRLM LIDFEYSSYN YRGFDIGNFF CEWTYDYTYD
KFPFFTNNTK NYPTKAQQMH IFHSYLLESD AGFKHLSEED QMKLKEDMLV EVNRFALASH
FFWGLWSMIQ AKISTIEFGY MEYAMARFDA YFELKRKLGV
//