ID Q1LWK8_DANRE Unreviewed; 489 AA.
AC Q1LWK8; A0A8M1N9N8;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Major facilitator superfamily domain-containing 12a {ECO:0000313|Ensembl:ENSDARP00000083300, ECO:0000313|RefSeq:NP_001038437.1};
GN Name=mfsd12a {ECO:0000313|Ensembl:ENSDARP00000083300,
GN ECO:0000313|RefSeq:NP_001038437.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-4642};
GN Synonyms=fd45a11 {ECO:0000313|RefSeq:NP_001038437.1}, si:dkey-218h11.4
GN {ECO:0000313|RefSeq:NP_001038437.1}, wu:fd45a11
GN {ECO:0000313|RefSeq:NP_001038437.1}, wz7872
GN {ECO:0000313|RefSeq:NP_001038437.1}, zgc:158256
GN {ECO:0000313|RefSeq:NP_001038437.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000083300};
RN [1] {ECO:0000313|RefSeq:NP_001038437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038437.1};
RX PubMed=12036288;
RA Iovine M.K., Johnson S.L.;
RT "A genetic, deletion, physical, and human homology map of the long fin
RT region on zebrafish linkage group 2.";
RL Genomics 79:756-759(2002).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000083300, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000083300};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000083300}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000083300};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001038437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038437.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001038437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038437.1};
RX PubMed=29025994; DOI=10.1126/science.aan8433;
RG NISC Comparative Sequencing Program;
RA Crawford N.G., Kelly D.E., Hansen M.E.B., Beltrame M.H., Fan S.,
RA Bowman S.L., Jewett E., Ranciaro A., Thompson S., Lo Y., Pfeifer S.P.,
RA Jensen J.D., Campbell M.C., Beggs W., Hormozdiari F., Mpoloka S.W.,
RA Mokone G.G., Nyambo T., Meskel D.W., Belay G., Haut J., null,
RA Rothschild H., Zon L., Zhou Y., Kovacs M.A., Xu M., Zhang T., Bishop K.,
RA Sinclair J., Rivas C., Elliot E., Choi J., Li S.A., Hicks B., Burgess S.,
RA Abnet C., Watkins-Chow D.E., Oceana E., Song Y.S., Eskin E., Brown K.M.,
RA Marks M.S., Loftus S.K., Loftus S.K., Pavan W.J., Yeager M., Chanock S.,
RA Tishkoff S.A.;
RT "Loci associated with skin pigmentation identified in African
RT populations.";
RL Science 358:eaan8433-eaan8433(2017).
RN [6] {ECO:0000313|RefSeq:NP_001038437.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038437.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX548024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038437.1; NM_001044972.1.
DR STRING; 7955.ENSDARP00000083300; -.
DR Ensembl; ENSDART00000088867; ENSDARP00000083300; ENSDARG00000061908.
DR Ensembl; ENSDART00000088867.5; ENSDARP00000083300.4; ENSDARG00000061908.6.
DR GeneID; 561964; -.
DR KEGG; dre:561964; -.
DR AGR; ZFIN:ZDB-GENE-030131-4642; -.
DR CTD; 561964; -.
DR ZFIN; ZDB-GENE-030131-4642; mfsd12a.
DR HOGENOM; CLU_030068_1_1_1; -.
DR OrthoDB; 2902828at2759; -.
DR TreeFam; TF314080; -.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000061908; Expressed in early embryo and 23 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR CDD; cd17491; MFS_MFSD12; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11328:SF28; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF13347; MFS_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 489 AA; 54164 MW; 73F6C944240F2B6B CRC64;
MQDSSEASLP VIRRLSYSVG HFLNDLCASM WFTYLLVFYH SVLGFENTYA GVLLLVGQIA
DGVCTPLIGY ESDRTPGCGS YGKRKTWHLV GTISVLLSFP FIFNQCLGCD LNTPQWVSVT
YFAPFIIIFQ FGWAATQISH LSLIPELVSC EHEKVELTAY RYAFTVIANI TVYAVAWLLF
HFQEGDDPAV MDNLGPVDIP VFRNLSLIVV GIGAVFTFLF HLGTREKGRP FQEEDGSSPG
ERQPLINNTT VAPPANLLHW NNWLTQPSFY QVALLYMSTR LIVNLSQTYI SMYLTYTLLL
PKNYIATIPL VMFLSGFASS FIMKPVSKLI GKCMTYFLGL LLILAFSYWV LLDTHMGDKV
YGAAVLLGVG SATILVMSLA MTAELIGDQT HSGAFVYGAM SFTDKVANGL GVMIIQTLHP
CRTMVCCPAC VWYYHYVMVI VSGGVAVLAA LSLCTILIWP IKIVRYLPEV AGLMESDEDS
ESSEQPSVN
//
