ID Q1NGH9_SPHSS Unreviewed; 443 AA.
AC Q1NGH9;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 13-SEP-2023, entry version 69.
DE RecName: Full=C4-dicarboxylate transport protein {ECO:0000256|HAMAP-Rule:MF_01300};
GN Name=dctA {ECO:0000256|HAMAP-Rule:MF_01300};
GN ORFNames=SKA58_05445 {ECO:0000313|EMBL:EAT09876.1};
OS Sphingomonas sp. (strain SKA58).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=314266 {ECO:0000313|EMBL:EAT09876.1, ECO:0000313|Proteomes:UP000005395};
RN [1] {ECO:0000313|EMBL:EAT09876.1, ECO:0000313|Proteomes:UP000005395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SKA58 {ECO:0000313|EMBL:EAT09876.1,
RC ECO:0000313|Proteomes:UP000005395};
RA Hagstrom A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate across the membrane.
CC {ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01300}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|ARBA:ARBA00006148,
CC ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAT09876.1}.
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DR EMBL; AAQG01000002; EAT09876.1; -; Genomic_DNA.
DR RefSeq; WP_009820865.1; NZ_CH959306.1.
DR AlphaFoldDB; Q1NGH9; -.
DR STRING; 314266.SKA58_05445; -.
DR eggNOG; COG1301; Bacteria.
DR HOGENOM; CLU_019375_7_0_5; -.
DR OrthoDB; 9766690at2; -.
DR Proteomes; UP000005395; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865:SF1; AEROBIC C4-DICARBOXYLATE TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR42865; PROTON/GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01300};
KW Reference proteome {ECO:0000313|Proteomes:UP000005395};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|HAMAP-Rule:MF_01300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01300}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 358..387
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
SQ SEQUENCE 443 AA; 46413 MW; 267FA9A373A1F2A0 CRC64;
MMPSPSSPIQ TAPRLPFYRQ LYVQVLVAIA LGVAIGHFFP DAGVQLKPLG EAFIKLVKMI
IAPVIFLTIV TGIAGMKELG AIGRVAAKAF GYFLTFSTLA LIVGLIVANV VQPGAGLNID
PATLDAGKVA DYAHQAHERT LTGFLMSIIP ATMVSAVADG NILQVLFVAI LFGIALTMIG
DKAAPLMTVL ESASHAVFKL VGFLMKAAPI GAFGAMAFTI GEYGVGTLAN LAGLVATFYL
TSLLFVLVVL GAVCWAVGFN ILHLIRYLKA ELLLVLGTSS SEAALPSLIE KMERAGCRKS
VVGLVVPTGY SFNLDGTNIY MTLAALFIAQ ACNVHISLEE QILLLLVAMI SSKGAAGVTG
AGFITLAATL SIVPSVPVAG MTLILGVDRF MSECRSLTNF VGNAVATVVV SVWEKGLDRE
RFTAAMAGIP LDPTPDMQEV VPD
//
