ID Q1QF85_NITHX Unreviewed; 1069 AA.
AC Q1QF85;
DT 16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Heavy metal efflux pump CzcA {ECO:0000313|EMBL:ABE65112.1};
GN OrderedLocusNames=Nham_4533 {ECO:0000313|EMBL:ABE65112.1};
OS Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14).
OG Plasmid pNITHX2 {ECO:0000313|Proteomes:UP000001953}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Nitrobacter.
OX NCBI_TaxID=323097 {ECO:0000313|EMBL:ABE65112.1, ECO:0000313|Proteomes:UP000001953};
RN [1] {ECO:0000313|Proteomes:UP000001953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10229 / NCIMB 13809 / X14
RC {ECO:0000313|Proteomes:UP000001953};
RC PLASMID=Plasmid pNITHX2 {ECO:0000313|Proteomes:UP000001953};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L.,
RA O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T.,
RA Gentry M.E., Bruce D., Richardson P.;
RT "Complete sequence of plasmid 2 of Nitrobacter hamburgensis X14.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000321; ABE65112.1; -; Genomic_DNA.
DR RefSeq; WP_011505034.1; NC_007960.1.
DR AlphaFoldDB; Q1QF85; -.
DR KEGG; nha:Nham_4533; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_5; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000001953; Plasmid pNITHX2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:ABE65112.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001953};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1069 AA; 114671 MW; E4E6A9941BB107D8 CRC64;
MIDGILSFAI RQRWLVMIGV LAMAAFGAWN FTRLPIDAVP DITNVQVQIN SSAPGYSPLE
VEQRITFPIE TAMGGLPHLD STRSQSRYGL SQVTIIFKDG TDIYFARQLV NERIQQVKDQ
LPAGVETAMG PISTGLGEIY LFTVEAKPGA RKEGGGDYTP SDLRTIQDWI IKPQLRNVPG
VIEVNTIGGF EKQFHVLPDP AQLMAYKLSF RDVMTALASN NANVGAGYIE RNGEQYLVRT
PGQVANVEDI KEIVIGSHNG VPVRIGDVAE VREGKDLRTG AATVNGKETV LGTVMLLIGE
NSRAVAQRVA AKLKEIGRSL PDGVIARAVY DRTHLVEATV ATVEKNLVEG ALLVIVILFM
ILGNFKAAIA TACVIPLAML FTITGMVENK VSANLMSLGA IDFGIIIDGA VIIVENCLRL
LAEEQHRQGR LLNRQERFET ILAGSREVIG PSLFGTLIIG VVYLPILTLT GVEGKMFTPM
ALTVLMALTG ASILSLTFVP AAVALLVTGK VSEHENVFMR GARKLYTPLL AASIRNRFGV
AAIAALLVVV CGIAATRMGG EFIPSLDEGD VALQAIRIPG TSLTQSLEMQ AMLEKRLLKI
PEVKEAFART GTAEVATDLM PPSTSDGYVM LKPRKEWPDP EKSKAAVVRE IQEAAEEIPG
NVYEISQPIE QRFNELISGV RSDVGIKIFG DDLDTLVQSA AKVQAVLQNV EGAADVKTEQ
ASGLPVLTVK LNRQALSRYG INVSDVQNLI EIAVGGKPSG LVFEGDRRFD IVVRLPEHLR
SDMEAIRALP VPLPPLENNA KATPAVWNNS PLAQIRYVPL SELAEIDVAL GPNQISRENG
KRRIVVTANV RGRDLGSFVA DAQKQVEEKV KLPAGYWIGW GGQFEQLVSA TQRLTIVVPI
ALLLILLLLF MSLGSMADAL LVFSGVPLAL TGGIVALLLR GIPLSISAGI GFIALSGVAV
LNGLVIITFI EGLRREGHAL VDAVREGALT RLRPVLMTAL VASLGFVPMA IATGAGAEVQ
RPLATVVIGG IISSTILTLL VLPALYVLFR REEPENGGSN LPTVGGVNP
//
