GenomeNet

Database: UniProt
Entry: Q1RI08
LinkDB: Q1RI08
Original site: Q1RI08 
ID   PRIA_RICBR              Reviewed;         648 AA.
AC   Q1RI08;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-OCT-2019, entry version 93.
DE   RecName: Full=Primosomal protein N' {ECO:0000255|HAMAP-Rule:MF_00983};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983};
DE   AltName: Full=ATP-dependent helicase PriA {ECO:0000255|HAMAP-Rule:MF_00983};
GN   Name=priA {ECO:0000255|HAMAP-Rule:MF_00983};
GN   OrderedLocusNames=RBE_0925;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Involved in the restart of stalled replication forks.
CC       Recognizes and binds the arrested nascent DNA chain at stalled
CC       replication forks. It can open the DNA duplex, via its helicase
CC       activity, and promote assembly of the primosome and loading of the
CC       major replicative helicase DnaB onto DNA. {ECO:0000255|HAMAP-
CC       Rule:MF_00983}.
CC   -!- SUBUNIT: Component of the primosome. {ECO:0000255|HAMAP-
CC       Rule:MF_00983}.
CC   -!- SIMILARITY: Belongs to the helicase family. PriA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00983}.
DR   EMBL; CP000087; ABE05006.1; -; Genomic_DNA.
DR   RefSeq; WP_011477587.1; NC_007940.1.
DR   SMR; Q1RI08; -.
DR   STRING; 336407.RBE_0925; -.
DR   EnsemblBacteria; ABE05006; ABE05006; RBE_0925.
DR   KEGG; rbe:RBE_0925; -.
DR   HOGENOM; HOG000037414; -.
DR   KO; K04066; -.
DR   OMA; RCHYCGY; -.
DR   OrthoDB; 1132322at2; -.
DR   BioCyc; RBEL336407:G1G4P-1334-MONOMER; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.8.630; -; 1.
DR   HAMAP; MF_00983; PriA; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005259; PriA.
DR   InterPro; IPR041222; PriA_3primeBD.
DR   InterPro; IPR042115; PriA_3primeBD_sf.
DR   InterPro; IPR041236; PriA_C.
DR   InterPro; IPR040498; PriA_CRR.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF17764; PriA_3primeBD; 1.
DR   Pfam; PF18074; PriA_C; 1.
DR   Pfam; PF18319; PriA_CRR; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00595; priA; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Metal-binding; Nucleotide-binding; Primosome;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    648       Primosomal protein N'.
FT                                /FTId=PRO_0000281069.
FT   DOMAIN      131    297       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00983}.
FT   DOMAIN      393    548       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00983}.
FT   NP_BIND     144    151       ATP. {ECO:0000255|HAMAP-Rule:MF_00983}.
FT   ZN_FING     358    370       C4-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00983}.
FT   ZN_FING     385    401       C4-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00983}.
FT   MOTIF       240    243       DEAH box.
SQ   SEQUENCE   648 AA;  73480 MW;  938DCF7E8739303A CRC64;
     MQIAKILLSA VKLFPLDYLI PEDLSLNIGD LVVVPFRNKE LTGIVWEFSN VPEVKKLKTI
     KEKVPLNLTI TSEVLDLIKW MSNYYMAELG SIAKLVLPVD IAEKPIKVKE QKINNNFTLP
     DLSEEQKQAL QMLNDSNKPI LIKGVTGSGK TEVYFYLIAE YLAKGKQALV MLPEIALSTQ
     IINRFKERFG FDPIIWNSSV TKAQKKMILR GILEDKVKIV IGARSSLFLP FKNLGLIVID
     EEHDDSYKQD DGVLYNARDT AIVRSTFDKA QIVLCSATPS IETMYNANIG KYSVINLSSR
     YKNAVLPNIE MIDMTKEELP KNCYLSNILI KAIKNNLENK EQTLLFLNRR GYAPLMLCKS
     CGHKFTCKYC SSWMVVHKSS KKLECHHCGY QSKIFNSCPE CLEDESLAIC GPGIERIEEE
     AKTLFPNSKI AVISKDHVKN PEKIAQLLHQ MENLEIDILI GTQMITKGYH FPNLTLVGVV
     DADLGSNHAD LRSSERAFQL LHQVGGRAGR GNSKGMVYLQ SYYPDNIIFS YIKDEREDNF
     FVNELEVRKA ADMPPFSKMA SVILSGTNEH KILEVAKNMV RIAPEAQVKI LGPASSLMSK
     LAGKYRFRIL IIADKKFNLQ KYLKFWLELI KIPSFCHIKI DIDPKSFY
//
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