ID Q1RL59_CIOIN Unreviewed; 537 AA.
AC Q1RL59; A0A1W2VU27;
DT 16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Zinc finger protein {ECO:0000313|EMBL:FAA00206.1, ECO:0000313|Ensembl:ENSCINP00000030145.1};
GN Name=Ci-ZF(ZZ)-4 {ECO:0000313|EMBL:FAA00206.1};
GN Synonyms=zf(zz)-4 {ECO:0000313|Ensembl:ENSCINP00000030145.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:FAA00206.1};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|EMBL:FAA00206.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16519883; DOI=10.1016/j.ydbio.2006.01.024;
RA Miwata K., Chiba T., Horii R., Yamada L., Kubo A., Miyamura D., Satoh N.,
RA Satou Y.;
RT "Systematic analysis of embryonic expression profiles of zinc finger genes
RT in Ciona intestinalis.";
RL Dev. Biol. 292:546-554(2006).
RN [3] {ECO:0000313|Ensembl:ENSCINP00000030145.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01002558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BR000175; FAA00206.1; -; mRNA.
DR RefSeq; NP_001122363.1; NM_001128891.1.
DR STRING; 7719.ENSCINP00000030145; -.
DR Ensembl; ENSCINT00000033763.1; ENSCINP00000030145.1; ENSCING00000021400.1.
DR GeneID; 100169910; -.
DR KEGG; cin:100169910; -.
DR CTD; 100169910; -.
DR GeneTree; ENSGT00940000166230; -.
DR HOGENOM; CLU_507075_0_0_1; -.
DR OrthoDB; 2880153at2759; -.
DR Proteomes; UP000008144; Chromosome 7.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR CDD; cd16243; EFh_DYTN; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF18; DYSTROTELIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 235..292
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 437..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 351..424
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 437..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 60801 MW; F27BEC3823C0CD06 CRC64;
MESLNKSGDT KKELDKLITK ITLEFHDIKF SVYRTSLKLG RIQDAFHLRG ITTTTLYSKV
KKLILNKTNT SIDNVTTEGM NYEELEGLVR SLYHDSLSKV SKKLCECLCT LVFQTFQDFT
ENRVSVIAVV LFFIILGGEE LVKKYKLLFS LYSGSLRMLT RSRCGLMLAH CVRLTDVVGE
DINFGNISSA IASCFSGVLG ASISEQQLLQ WLFKEPQSLV WLPTMHRLNL AKSSVHEVQC
AECKIRPIIG LRFQCLKCLD YDTCHHCFLT QSNSSRSHKL NHPRQEYCTP AGGREKVNAF
ARTIRNIVTK RYKQKPLSSS FLPIDQSPSS DNVVMETRDK LNESSDFVEI NHLAAAEREE
LEKLVSKLKE ENDKMSGTVQ LLESTKHDVP SNEIEDRLIL QSHLDTVTQQ NKSLQSELDN
LKCVVFADDF MTTGKSQSHH ELSANQSEVS ESCDERSTNK KTAKKRKKRA PRPTPEGDKD
NEFVVDENMA GGLEAHLHHL VDRLGRNDED GEMEDVVNAM VDAGEMFIRL LDVILVN
//
