ID C5083_DICDI Reviewed; 479 AA.
AC Q1ZXL7; Q556M6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=Probable cytochrome P450 508A3;
DE EC=1.14.-.-;
GN Name=cyp508A3-1; ORFNames=DDB_G0273047;
GN and
GN Name=cyp508A3-2; ORFNames=DDB_G0273941;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000009; EAS66922.1; -; Genomic_DNA.
DR EMBL; AAFI02000011; EAL70404.2; -; Genomic_DNA.
DR RefSeq; XP_001134606.1; XM_001134606.1.
DR RefSeq; XP_644329.2; XM_639237.2.
DR AlphaFoldDB; Q1ZXL7; -.
DR SMR; Q1ZXL7; -.
DR STRING; 44689.Q1ZXL7; -.
DR PaxDb; 44689-DDB0232351; -.
DR EnsemblProtists; EAL70404; EAL70404; DDB_G0273941.
DR EnsemblProtists; EAS66922; EAS66922; DDB_G0273047.
DR GeneID; 8618759; -.
DR GeneID; 8619217; -.
DR KEGG; ddi:DDB_G0273047; -.
DR KEGG; ddi:DDB_G0273941; -.
DR dictyBase; DDB_G0273047; cyp508A3-1.
DR dictyBase; DDB_G0273941; cyp508A3-2.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; Q1ZXL7; -.
DR OMA; SYELCFI; -.
DR PhylomeDB; Q1ZXL7; -.
DR PRO; PR:Q1ZXL7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20617; CYP1_2-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24303:SF31; CYTOCHROME P450 307A1-RELATED; 1.
DR PANTHER; PTHR24303; HEME-BINDING MONOOXYGENASE FAMILY; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..479
FT /note="Probable cytochrome P450 508A3"
FT /id="PRO_0000318808"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 424
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 479 AA; 56038 MW; 04A4BA64B9F18D8E CRC64;
MEFLKLILFL IIFYIIHNTY IKFKKINKNE LKGPIPIPIL GNLYQLTSGL PHRDLTKISE
KYGGIYRFWF ADLYTVVLSD PILIREMFVN NGDYFLDRPK IPSIRHATHY HGIATSSGEY
WLKIRDIINK AMRKTNLKLI YDSLDQQVDN LIESMNKIES DGQVFEPRIY FKKYTMAAMY
KFIFNEEINF NNEISELIGP IEQVFKDLGS GSLFDVLLIS RPLYYQWIEH TDKNYPKILN
FLKKKYHQHL KTYNPEIQRD LLDLLIKEYY SGSDDDILTI IATINDLFLA GTDTSSASLE
YMVMMLVNYP EIQEKVYDEI KLTVNGRNKV LLSDRQFTPY TVSFIKETLR YKPPSSVGVP
RTTSQDIIIG DKFIPKDAQI FINYYGLSRN QDYFENPEQF EPSRFMNPDT NIAFLPFSIG
TRNCVGQNFA LDEMFLAFSN IILNFKFSSI DGKQIDETEL YGVTLRCKNK FNVSIKKRI
//
