ID Q20068_CAEEL Unreviewed; 493 AA.
AC Q20068;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 2.
DT 27-MAR-2024, entry version 153.
DE RecName: Full=Tubulin-specific chaperone E {ECO:0000256|ARBA:ARBA00015004};
DE AltName: Full=Tubulin-folding cofactor E {ECO:0000256|ARBA:ARBA00030180};
GN Name=tbce-1 {ECO:0000313|EMBL:CCD70598.1,
GN ECO:0000313|WormBase:K07H8.1};
GN ORFNames=CELE_K07H8.1 {ECO:0000313|EMBL:CCD70598.1}, K07H8.1
GN {ECO:0000313|WormBase:K07H8.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70598.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70598.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70598.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TBCE family.
CC {ECO:0000256|ARBA:ARBA00006286}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284604; CCD70598.1; -; Genomic_DNA.
DR PIR; T16278; T16278.
DR PIR; T33025; T33025.
DR RefSeq; NP_501395.1; NM_068994.4.
DR AlphaFoldDB; Q20068; -.
DR SMR; Q20068; -.
DR STRING; 6239.K07H8.1.1; -.
DR EPD; Q20068; -.
DR PaxDb; 6239-K07H8-1; -.
DR PeptideAtlas; Q20068; -.
DR EnsemblMetazoa; K07H8.1.1; K07H8.1.1; WBGene00019503.
DR GeneID; 177624; -.
DR KEGG; cel:CELE_K07H8.1; -.
DR UCSC; K07H8.1; c. elegans.
DR AGR; WB:WBGene00019503; -.
DR WormBase; K07H8.1; CE18021; WBGene00019503; tbce-1.
DR eggNOG; KOG3207; Eukaryota.
DR GeneTree; ENSGT00530000063405; -.
DR HOGENOM; CLU_017716_5_0_1; -.
DR InParanoid; Q20068; -.
DR OMA; NENSTFA; -.
DR OrthoDB; 11880at2759; -.
DR PhylomeDB; Q20068; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00019503; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IBA:GO_Central.
DR GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR CDD; cd17044; Ubl_TBCE; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR044994; TBCE.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR044079; Ubl_TBCE.
DR PANTHER; PTHR15140; TUBULIN-SPECIFIC CHAPERONE E; 1.
DR PANTHER; PTHR15140:SF31; TUBULIN-SPECIFIC CHAPERONE E; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 1: Evidence at protein level;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|EPD:Q20068,
KW ECO:0007829|PeptideAtlas:Q20068};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 30..65
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
SQ SEQUENCE 493 AA; 56713 MW; 8A9CE4CB391907DA CRC64;
MEIGQRVRIN FEVATVRYIG EVDGYGSQRW VGLEWDDPTR GKHDGIVRGK RYFQTRHPNG
GSLMKHEIVP KPTDLLFEIK DRYIEEESVE TEIELAQSNK KIELIGMDQT AAKQSNIEKL
INIVLDNRSV GFPPSSDSPQ FILCRELNLY GNLLYKWKTV RQILEYFPRI QELNLRRNRM
QCFNEEEDDD ESEGDDHVYS DSCKKLVISE CNLSENSIDS ILLRFPSTSD VVAFGNDLTR
FSVSEAVSSR LTSLDLEDNP FKTLDSIHGT FPNLTQLSVA NCGITSLNGF DGSIKFPKLE
YLNIKRNSIV EWKSVNSIRS LKSLKRLLFD CKKLSTEKGV HAYEIVIAKL STLIDLNRFD
VSEVERRSAE IRFLNKYAGL NDNEDHQDDI KRLIEIHGEP TLDTAKKGLA VVKIRIECGN
RVETRRLPLG MSIQKIRDML ARLFKVPNTS KIRLYLVMSE KAKQHRIELE NPLREFGHYS
PSEDRDILVV EHD
//
